To our knowledge, this study is the first to define clinical features that may serve as clues in the diagnosis of MCC. The most significant features can be summarized in an acronym: AEIOU (asymptomatic/lack of tenderness, expanding rapidly, immune suppression, older than 50 years, and ultraviolet-ex …

We define the “AEIOU Features of MCC” which are Asymptomatic (non-tender), Expanding Rapidly, Immune suppression, Older than age 50, and UV exposed/fair skin. Merkel cell carcinoma (MCC) is an aggressive skin cancer with a mortality of 33%.

2017年1月1日 · Heath et al. developed the AEIOU acronym to define the clinical features associated with MCC: asymptomatic/lack of tenderness, expanding rapidly, immune suppression, older than age 50 and UV-exposed site on a person with fair skin. In a study of 195 patients, 89% presented with three or more of the AEIOU characteristics [4].

We identified several tumor characteristics that may aid a clinician in suspecting MCC, summarized as AEIOU (Table V). Of particular note, we consider lack of tenderness an important feature in MCC as many other lesions that are rapidly growing and red or pink (such as an inflamed cyst, the most common presumed diagnosis) would likely be tender.

We identified several tumor characteristics that may aid a clinician in suspecting MCC, summarized as AEIOU (Table V). Of particular note, we consider lack of tenderness an important feature in MCC as many other lesions that are rapidly growing and red or pink (such as an inflamed cyst, the most common presumed diagnosis) would likely be tender.

2024年4月27日 · The majority of primary MCC's will have ≥ 3 of the following features captured by the acronym AEIOU: asymptomatic, expanding rapidly, immune suppression, older than 50 years, and ultraviolet radiation-exposed.

Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years. This article reviews the recent advancement in diagnosis, discoveries in pathogenesis, and updates in management. The acronym, AEIOU, has been propose …

According to one study, the five most common features of MCC at presentation are asymptomatic or lack of tenderness (88%), rapid expansion (63%), immunosuppression (7.8%), older than 50 years of age (90%), and location on UV exposed skin (81%) - leading to the development of the acronym AEIOU to aid in diagnosis.

2025年2月28日 · “AEIOU” summarizes the features that are usually associated with MCC. 89% of MCC tumors have three or more of these five features: A: Asymptomatic—88% of MCCs are not tender.

Merkel cell carcinoma (MCC) is a highly aggressive and rare skin cancer. MCC most commonly occurs in elderly Caucasians, and it is slightly more prevalent in men. The risk factors for MCC are similar to that of other skin cancers, specifically older age, fair skin, ultraviolet light exposure, male gender, and immunosuppression.