First Cancer TCR Cell Therapy Approved by FDA - NCI
2024年8月27日 · On August 2, the Food and Drug Administration (FDA) approved a cellular therapy called afamitresgene autoleucel, or afami-cel (Tecelra), to treat some people with …
Afami-cel :: Adaptimmune (ADAP)
Afamitresgene autoleucel (“afami-cel”; formerly ADP-A2M4) is directed to a member of the MAGE family of cancer testis antigens expressed in a number of solid tumor cell types. The MAGE- …
TECELRA® (afami-cel) is the first TCR-T cell therapy for solid …
In August 2024, the U.S. Food & Drug Administration (FDA) granted afami-cel (TECELRA®) accelerated approval to treat adults with unresectable or metastatic synovial carcinoma.¹ The …
Adaptimmune Receives U.S. FDA Accelerated Approval of TECELRA ...
2024年8月2日 · PHILADELPHIA & OXFORD, England-- (BUSINESS WIRE)-- Adaptimmune Therapeutics plc (NASDAQ: ADAP), a company working to redefine the treatment of solid …
FDA Approves First T-Cell Receptor Gene Therapy for Solid …
2024年8月6日 · The Food and Drug Administration granted accelerated approval on Friday to afamitresgene autoleucel (afami-cel), a T-cell receptor (TCR) gene therapy, to treat certain …
Afamitresgene autoleucel for advanced synovial sarcoma and ... - The Lancet
2024年4月13日 · Afami-cel is an autologous T-cell receptor T-cell therapy engineered to express an affinity-enhanced T-cell receptor specifically targeting a MAGE-A4 antigen presented on …
Autologous T cell therapy for MAGE-A4 - Nature
2023年1月9日 · Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted …
总有效率近40%，TCR-T细胞疗法Afami-cel，有望加快上市 - 知乎
2024年3月5日 · Afami-cel是一种自体T细胞受体（TCR）T细胞疗法（TCR-T），目的在于靶向表达黑色素瘤相关抗原A4（MAGE A4）的实体瘤中的癌症细胞，该蛋白在滑膜肉瘤中的表达程 …
Approval of the first TCR-based cell therapy - Cell Press
On August 2, 2024, the US Food and Drug Administration (FDA) approved afamitresgene autoleucel (afami-cel; Tecelra) for the treatment of metastatic or unresectable synovial …
SPEAR T细胞 | afami-cel 为实体瘤患者带来希望 - 知乎
2023年3月10日 · 主要在研管线afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) 是一种自体特异肽亲和力增强的 TCR-T细胞疗法，识别HLA-A*02 限制性 MAGE-A4230-239 肽 …