2020年12月15日 · Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs declines with age, thus...

2021年9月1日 · Here, we review age-related alterations of MSCs in musculoskeletal tissues, and address the underlying mechanisms of aging and senescence of MSCs. Furthermore, we focus on the properties of MSCs in osteoarthritis and osteoporosis, and how their changes contribute to onset and progression of these disorders.

2023年7月18日 · Ageing of stem cells (SCs) is involved in age-related diseases. MSCs are endowed with a potent immune suppression capacity in the inflammatory environment due to their ability to inhibit T, B, dendritic, and natural killer cell functions and to favour macrophage polarization no acquisition of an anti-inflammatory phenotype .

2024年11月17日 · It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs “age” similarly in vivo.

In this review, we will concisely discuss current progress on the detailed mechanisms of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised therapeutic efficacy of the senescent MSCs.

2024年5月10日 · Adult mesenchymal stem cells (MSCs) look like fibroblasts and can self-renew and specialize into osteoblasts, adipocytes, and chondrocytes. In early development, they come from the mesoderm and ectoderm and may be taken from bone marrow, adipose tissue, muscle tissue, amniotic fluid, umbilical cord, etc.

2023年7月20日 · Our results demonstrate that MSCs undergo a progressive aging process and that the cellular senescence state influences their immunosuppressive activity by downregulating PD-L1 expression....

2014年1月7日 · Aged MSCs displayed senescent features when compared with cells isolated from young donors, concomitant with reduced viability and proliferation. These features were also associated with significantly reduced differentiation potential in aged MSCs compared to …

2025年3月19日 · Taken together, these findings indicate that UC-MSCs may have potential therapeutic benefits for age-related changes seen within these important immune organs, and may be beneficial for preventing ...

2025年2月21日 · In the past, cell therapy involving the direct transplantation of mesenchymal stem cells (MSCs) has made significant progress in combating aging-related conditions, including osteoarthritis (OA) associated with physiological aging [10,11,12], cardiovascular diseases [13, 14], frailty in aging [15, 16], and neurodegenerative diseases [17, 18].MSC therapies have already carried out clinical ...