When discussing AKI and aging, one should consider two aspects: first, elderly patients have an increased susceptibility to an AKI episode, and second, they have decreased kidney repair after AKI given the high incidence of progression to chronic kidney disease (CKD).

Although aging increases susceptibility to acute kidney injury (AKI), whether the AKI risk and the association between AKI and adverse outcomes are age-dependent remain unclear in older adults. The current study aimed to identify whether AKI risk was age-dependent in older adults and to investigate whether the association between AKI and ...

The aging kidney undergoes a number of important anatomic and physiologic changes that increase the risk of acute kidney injury (formerly acute renal failure) in the elderly. This article reviews these changes and discusses the diagnoses frequently encountered in the elderly patient with acute kidney injury.

2024年7月18日 · Multiple studies have shown that the ageing process markedly amplifies the risk of acute kidney injury (AKI) and chronic kidney disease (CKD), thereby imposing substantial burdens on society and...

2019年12月5日 · Acute kidney injury (AKI) increases the risk of end stage renal disease among the elderly, but the precise underlying mechanism is unknown. We investigated the effects of aging on...

2009年11月1日 · The overall incidence of AKI is increasing steadily, and this is particularly true in elderly individuals. There are a number of biological aspects of aging that heighten the risk of developing AKI. Current means of treating AKI are limited, other than conservative management and dialytic support as needed.

2024年9月17日 · In this review, we discuss the recent advances in experimental as well as preclinical and clinical research in renal aging and AKI with special references to different epigenetic regulations, such as DNA methylation, histone alterations, non-coding RNA regulation, and/or changes in microRNA.

2013年5月1日 · it is well known that the incidence of acute kidney injury (AKI) increases with advancing age (2). Conceivably, it is related to the age-related functional and structural changes in the kidney that render the elderly population highly susceptible to AKI.

2014年3月1日 · The incidence of acute kidney injury (AKI) is rising in individuals of all ages; however, elderly patients (older than 65 years) are particularly susceptible to the development of AKI due to the structural and functional deterioration of the kidneys associated with the aging process, a decreased renal reserve, the presence of comorbidities, and ...

When discussing AKI and aging, one should consider two aspects: first, elderly patients have an increased susceptibility to an AKI episode, and second, they have decreased kidney repair after AKI given the high incidence of progression to chronic kidney disease (CKD).