2021年10月15日 · Here, we generate a metabolome atlas of the aging wildtype mouse brain from 10 anatomical regions spanning from adolescence to old age. We combine data from three assays and structurally...

2025年3月26日 · Taxonomic and functional description of the mouse microbiome. We studied the effects of aging in 52 male wild-type C57BL/6J/Ukj mice, separated into 5 age groups between 2 months and 30 months old ...

2024年10月2日 · Based on our in-depth proteomic data and sample-matched transcriptome data of adult, middle-aged, old, and geriatric mice, we construct the Mouse aging proteomic atlas...

2025年3月5日 · Expression of the Xi escapee Plp1, a myelin component, was increased in the aging hippocampus of female mice and parahippocampus of women. AAV-mediated Plp1 elevation in the dentate gyrus of aging male and female mice improved cognition. Understanding how the Xi may confer female advantage could lead to novel targets that counter brain aging ...

2025年3月27日 · The researchers used a targeted protein treatment on older mice to help these meningeal lymphatics grow and operate. In subsequent experiments, the treated mice were shown to have improved memory function compared to untreated animals. The researchers looked at meningeal lymphatics and their waste removal, and microglia immune cells.

2025年3月7日 · Systematic investigations demonstrated that citrulline exhibited antiaging effects by reducing cellular senescence, protecting against DNA damage, preventing cell cycle arrest, modulating macrophage metabolism, and mitigating inflammaging.

2024年7月18日 · In this review, we present a comprehensive overview of the characteristics, limitations, applicability, bone phenotypes, and treatment methods in naturally aging mice and prematurely aging mouse models (including SAMP6, POLG mutant, LMNA, SIRT6, ZMPSTE24, TFAM, ERCC1, WERNER, and KL/KL -deficient mice).

2025年3月29日 · The idea is that older mice will spend roughly the same amount of time playing with either type of object, while younger mice will be more drawn to the novel trinket. ... "Therapies that support ...

For aging and aging-related chronic disorders, mice have become one of the most important animal models for studying various aging-related human diseases due to their similarities to humans in terms of genetic background and the structure and function of various organs or systems, as well as the advantages of short lifespan and ease of reproduct...

2025年3月24日 · Caloric restriction is associated with slow aging in model organisms. Additionally, some drugs have also been shown to slow aging in rodents. To better understand metabolic mechanisms that are involved in increased lifespan, we analyzed metabolomic differences in six organs of 12-month-old mice using five interventions leading to extended longevity, specifically caloric restriction, 17-α ...