2020年11月17日 · RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary …

3 天之前 · Also, the slicing capabilities of AGO2-AGO3 rely on different miRNA lengths 2,74,75 and there are reports of specific activating miRNAs per AGO 76. Thus, evidence suggests a …

Ago2与Ago3内切过程的比较。 可见Ago3切割mRNA，不仅要求cityRNA，还要求cityRNA结合的位点在mRNA的中间位置、必须要有侧翼序列，不能在mRNA的接近5’端或3’端的位置进行切割。

在AGO1、AGO2、AGO3和AGO4这四个人体Argonaute蛋白中，只有AGO2蛋白表现出了切割活性。AGO1蛋白和AGO4蛋白中的基序都和那段保守的天冬氨酸-天冬氨酸-组氨酸基序不同， …

Argonaute (AGO)：最近的研究表明，PAZ结构域结合到 siRNA 的3’的二 核苷酸 突出端；一些AGO蛋白质的PIWI结构域赋予slicer以内切酶的活性。 PAZ和PIWI两个结构域，对于siRNA和 …

2022年6月23日 · AGO incorporates a miRNA duplex, ejects the passenger strand (green), and forms the RISC with the remaining guide strand (red). The effector complexes of all four …

2022年7月8日 · MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional …

2013年6月4日 · Recently identified novel functions of AGO clade proteins include transcriptional silencing processes, alternative splicing and DNA double-strand break repair. Small-RNA …

We closely investigated the 10 most abundant miRNAs in Ago1, Ago2 and Ago3 and found that several highly abundant miRNA species are found associated with all three Ago proteins …

2016年4月18日 · AGO3 has approximately 70% sequence identity with AGO2, leading to a prevailing model that AGO3 might function redundantly with AGO2. AGO2 is a key component …