2025年2月25日 · Ago2 facilitated miRNA targeting of phosphatase and tensin homolog (Pten) mRNA, which encodes a phosphatase that modulates reelin-dependent phosphatidylinositol 3 …

Wang et al. show that AGO2 suppresses tumor cell responses to IFN-γ by promoting its interaction with miR-1246, thereby impairing STAT1 activation and subsequently inhibiting …

2023年9月18日 · Here we show that siRNA pathway disruption by CRISPR/Cas9-based Ago2 knockout impaired the mosquitoes’ ability to degrade arbovirus RNA leading to hyper-infection …

2025年3月6日 · Here, we show that exosomal siRNAs can be efficiently delivered into bacterial cells and can silence target genes primarily through translational repression without mRNA …

2025年3月6日 · (AGO2) protein forms a complex with siRNAs, which is essential for bacterial gene silencing. Both in vitro and in vivo-generated exosome-packaged siRNAs resensitize …

2024年7月30日 · Argonaute 2蛋白 （AGO2），亦称 真核翻译起始因子2C2 ( eukaryotic translation initiation factor 2C subunit 2，EIF2C2) 。含有N末端( amino-terminal) 、PAZ、MID …

2020年11月16日 · We identify 13 heterozygous mutations in AGO2 in 21 patients affected by disturbances in neurological development. Each of the identified single amino acid mutations …

Ago2 directly binds to the scaffolding domain of caveolin-1. Ago2 catalyzes miRNA maturation, and its interaction with other proteins affects miRNA function in cells (Muller et al, 2019). In …

The increased input of siAda-ExoAGO2-KD aims to achieve equal amount of siAda delivered into E. coli as samples treated with siAda-Exo. qRT-PCR analysis showed that the siAda content in …

2020年11月19日 · Argonaute (AGO) 蛋白是 RNA 介导的转录后基因调控的关键蛋白，为 miRNA 提供锚位点，形成 RNA 诱导沉默复合体 RISC 达到降解靶基因或者抑制翻译的目的。 自 …