2024年12月24日 · AGPAT4 (1-Acylglycerol-3-Phosphate O-Acyltransferase 4) is a Protein Coding gene. Diseases associated with AGPAT4 include Congenital Generalized Lipodystrophy and Ceroid Lipofuscinosis, Neuronal, 1. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism.

2015年12月1日 · Here, we report the results of our investigations on the subcellular localization, activity, and role of AGPAT4 in brain phospholipid composition using insect and mammalian cell culture models as well as Agpat4 gene knockout mice (Agpat4 −/−).

This gene has 6 transcripts (splice variants), 209 orthologues and 4 paralogues. Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues. 该基因编码 1-acylglycerol-3-phosphate O-acyltransferase 家族的成员。 这种完整的膜蛋白将溶血磷脂酸转化为磷脂酸，这是磷脂从头生物合成的第二步。 [RefSeq 提供，2008 年 7 月]

本文将详细介绍AGPAT4基因在细胞中的表达调控机制，包括其生物学功能、表达位置、调控网络以及与疾病的关系。 AGPAT4基因的基本信息. AGPAT4基因，全称为1-acylglycerol-3-phosphate O-acyltransferase 4，位于染色体6q26上。

2025年2月9日 · The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family.

在HEK293或Sf9昆虫细胞中过度表达的内源性大脑AGPAT4和AGPAT4定位于线粒体，并位于线粒体外膜上。 进一步的分离显示，AGPAT4专门存在于线粒体中，而不存在于与线粒体相关的内质网膜（即 MAM）中。 杆状病毒 Agpat4 感染的Sf9细胞的裂解 物 用8种溶血磷脂进行了测试，但仅用溶血磷脂酸作为酰基受体显示出增加的活性。 但是，对Sf9磷脂种类的分析表明，磷脂酰肌醇（PI）含量显着增加了72％。 我们检查了 Agpat4 - / - 小鼠大脑中主要磷脂种类的含量，发现 …

2020年3月27日 · We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4 (Agpat4) was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients.

2025年2月8日 · Findings indicate that Lpaatdelta deficiency causes deficits in learning and memory associated with reduced NMDA and AMPA receptors. findings indicate that AGPAT4 is a mitochondrial AGPAT/LPAAT that specifically supports synthesis of brain PI, PC, and PE. Enables 1-acylglycerol-3-phosphate O-acyltransferase activity.

AGPAT4的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码的1-酰基甘油-3-磷酸O-酰基转移酶家族的一个成员。这个完整的膜蛋白溶血磷脂酸转化为磷脂酸，在从头磷脂生物合成中的第二个步骤。 [由RefSeq的，2008年7月提供]

AGPAT4 is a member of a family of 1-acyl-sn-glycerol 3-phosphate acyltransferases (EC 2.3.1.51), also known as lysophosphatidic acid acyltransferases, that catalyze the acylation of lysophosphatidic acid to phosphatidic acid, the precursor …