Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis .

2024年12月24日 · Complete information for AGRN gene (Protein Coding), Agrin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium New to GeneCards?

Agrin is critical for neuromuscular junction development and was discovered in mouse knockout studies. It contains laminin G, Kazal-type serpin, and epidermal growth factor domains. Agrin Protein, Human (CHO, His) is the recombinant human-derived Agrin protein, expressed by CHO, with N-6*His labeled tag.

2022年8月26日 · 为了探讨Agrin是否能抑制hiPSC-CMs的成熟过程，采用3D贴片培养系统，分析了Agrin对hiPSC-CMs增殖和结构和功能成熟的影响。 长时间给药处理（100 ng/ml，两周）可促进CMs周期活性增加2倍（图5c）。

Agrin is expressed in neurons of developing and adult brain. Reduced agrin expression inhibits synapse formation in vivo and in vitro. Receptors and co-receptors of agrin regulate synaptic activity and plasticity. Agrin may promote synapse formation and …

Agrin is a widely expressed modular proteoglycan that consists of a core protein of ~220kDa with two glycosaminoglycan side chains that carry heparan sulfate and/or chondroitin sulfate. From: Seldin and Giebisch's The Kidney (Fifth Edition), 2013

2017年6月5日 · We identify agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts.

Agrin, a molecule produced by motoneurons that induces the aggregation of nicotinic acetylcholine receptors (nAChRs), has recently been structurally characterized. Agrin-related proteins (ARPs) that arise from differential splicing are synthesized by neurons and muscle.

2003年4月1日 · Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse ...

Agrin是一种与神经突触发展相关的聚集蛋白，近年来的研究证实Agrin在肿瘤与免疫中都发挥着重要的作用。 蛋白聚糖作为Agrin中的主要部分，是细胞外基质(extracellular matrix，ECM)的重要组成部分，与肿瘤发生过程相关，包括促进细胞生长、黏附与侵袭等 [ 1 ] 。