The respective AGS xenograft model provides an opportunity to understand the pattern of tumor growth as well as to evaluate new gastric cancer therapies in in vivo studies.

Our in vivo xenograft service department evaluates the efficacy of preclinical and clinical cancer therapeutics utilizing more than 50 validated immunocompromised xenograft mouse models. …

All clinically approved anti-cancer agents have been evaluated with conventional preclinical in vivo models. Xenograft studies can be highly complex, starting with the selection of the appropriate …

AGS cells displayed a codon 12 K-ras mutation, and all three cell lines were BRAF wild-type. In vitro, cetuximab significantly reduced cell viability and proliferation only in EGFR-positive/K-ras …

2023年1月31日 · Trametinib significantly induced AGS tumor regression at an orally administered dose of 3 mg/kg once per day (p < 0.05; Figure 3N). Collectively, these results led us to …

The respective AGS xenograft model provides an opportunity to understand the pattern of tumor growth as well as to evaluate new gastric cancer therapies in in vivo studies. Key Words: AGS, …

Based on the results in vitro, we evaluated the anti-tumor activity of B7H3-specific CAR-T cells in vivo. These in vivo results demonstrated the therapeutic potential of B7H3-specific CAR-T …

2011年10月20日 · Three human gastric cancer cell lines (AGS, MKN-45, NCI-N87) were evaluated for cell surface EGFR expression, and K-ras and BRAF mutations. In vitro, the …

2018年7月1日 · In vivo antitumor experiment showed that the nanoplatform could produce precise combined colorectal cancer chemotherapy and imaging-guided photothermal therapy under …

The cytotoxic effect of cisplatin on AGS cells in vitro was attenuated by recombinant human MK, but was promoted by suppressing MK expression via downregulating the Notch signaling …