We subsequently showed that AI-based workflow (AI-PTEN) could reliably detect PTEN loss in prostate cancer tissue cores, offering a streamlined objective biomarker assessment system 20.

2023年10月1日 · AI-PTEN showed high sensitivity (86%) and specificity (86%) for detecting PTEN loss compared with cPTEN as a reference on the core level (Supplementary Table S2) and AI-qPTEN achieved area under the receiver operating curve = 0.92 compared with cPTEN as a reference on the patient level.

2025年2月21日 · 研究人员们巧妙地利用荧光共振能量转移（FRET, Fluorescence resonance energy transfer）原理，将PTEN蛋白改造为构象敏感的"分子探针"。 通过在其N端和C端分别标记绿色荧光蛋白（mEGFP）与淬灭蛋白（sREACh），团队成功捕捉到PTEN从闭合态到开放态的构象转变，这种仅0.3纳秒的荧光寿命变化（从2.20 ns到2.53 ns），在双光子荧光寿命成像（2pFLIM, Two-photon fluorescence lifetime imaging microscopy）技术下清晰可辨。 更令人 …

Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and can be measured via immunohistochemistry. The purpose of the study was to establish the clinical application of an in-house developed artificial intelligence (AI) image analysis workflow for automat …

2020年9月3日 · Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and has clinical potential as a prognostic biomarker. The objective of this work was to develop...

Phosphatase and tensin homolog (PTEN) loss associates to adverse outcomes in prostate cancer and can be measured via immunohistochemistry (IHC). The purpose of the study was to establish the clinical application of an in-house developed artificial intelligence (AI) image analysis

Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and has clinical potential as a prognostic biomarker. The objective of this work was to develop an artificial intelligence (AI) system for automated detection and localization of PTEN loss on immunohistochemically (IHC) stained sections.

通过病理学家常规视觉评分 （cpten） 和基于 ai 的自动图像分析管道 （ai-pten） 独立评估来自金丝雀基金会 （n = 1264） 的术后组织微阵列切片，用抗 pten 抗体染色。

2023年6月1日 · This study demonstrates the clinical value of an affordable and fully automated AI-powered PTEN assessment for evaluating the risk of developing metastasis or disease recurrence after radical...

PTEN是迄今发现的第一个具有双重特性磷酸酶活性的肿瘤抑制基因，有 脂质磷酸酶 和 蛋白磷酸酶 双重特异性，在细胞内多条信号传导途径调控中起着重要作用，自发现以来受到众多学者的关注。 PTEN脂质磷酸酶的活性可使磷脂酰肌醇三磷酸（PIP3）去磷酸化转变为磷脂酰肌醇二磷酸而失活，继而抑制Pl3K/AKT通路，抑制细胞的生长、调控细胞周期。 癌细胞中PTEN功能的丧失几乎总是导致PIP3的积累和相关的AKT信号的激活。 癌症中PI3K途径效应子的下游激活是PTEN缺 …