2018年11月30日 · Autoimmune hemolytic anemia (AIHA) is a decompensated acquired hemolysis caused by the host’s immune system acting against its own red cell antigens. Consequent complement activation can impact the clinical picture and is an emerging target for therapeutic approaches. When a patient presents with anemia, a stepwise approach should be followed.

2023年9月11日 · Order CBC, reticulocyte count, hemolysis workup, DAT, and PBS. Consider warm AIHA in patients with: Laboratory evidence of hemolysis; DAT positive for IgG ± C3d not attributable to another cause (i.e., a recent transfusion or cold agglutinin) PBS: abundant spherocytes; Difficulty findings crossmatch-compatible blood units for transfusion

Autoimmune hemolytic anemia (AIHA) is characterized by hemolysis, i.e. the breakdown of red blood cells (RBCs) which occurs with autoantibodies and/or complement, together with activated macrophages, T-lymphocytes and cytokines all contributing to the process.

2024年10月10日 · Immune checkpoint inhibitors (ICPis) have revolutionized cancer immunotherapy but also can induce autoimmune hemolytic anemia (AIHA), a severe disease with high mortality. However, the cellular and molecular mechanism (s) of AIHA secondary to ICPi therapy (ICPi-AIHA) are unclear, other than being initiated through …

2016年12月22日 · The objective of this guideline is to provide healthcare professionals with guidance on the management of patients with primary autoimmune haemolytic anaemia (AIHA). The guidance may not be appropriate to every patient and in all cases individual patient circumstances may dictate an alternative approach.

2024年8月27日 · The direct antiglobulin test (DAT) or Coombs test is the cornerstone of AIHA diagnosis, as it is positive with anti-IgG in wAIHA, and with anti-C3d/IgM antisera plus high titer cold agglutinins in CAD. Therapy is quite different, as steroids and rituximab are effective in the former, but have a lower response rate and duration in the latter.

Autoimmune hemolytic anemia (AIHA) มีกลไกการเกิดมี 2 ประการคือ 1. กลไกการควบคุม B lymphocyte ที่ทาหน้าที่สร้างแอนติบอดีต่อเซลล์ตนเองเสียไป ซึ่งในภาวะปกติ

2024年4月12日 · Autoimmune hemolytic anemias (AIHAs) are conditions involving the production of antibodies against one’s own red blood cells (RBCs). These can be primary with unknown cause or secondary (by association with diseases or infections).

Warm Autoimmune Haemolytic Anaemia. In warm AIHA, the body produces an IgG autoantibody directed against a red cell antigen. This binds at body temperature, and results in opsonisation of the red cell. When the opsonised red cell encouters macrophages in the spleen, they are partly phagocytosed, resulting in membrane damage and haemolysis.

2025年1月3日 · This case highlights the importance of PBS in differentiating AIHA from pure red cell aplasia in patients with parvovirus B19 infection. Additionally, PBS can help reveal underlying red cell membrane disorders in patients with AIHA.