支架蛋白将信号组分定位在细胞的特定区域中，这个过程在信号中间物的局部产生中很重要。一个特别的例子是a型激酶锚定蛋白（akap），它将环腺苷酸依赖性蛋白激酶（即蛋白激酶a，pka）定位在细胞里的不同位置。

The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. [1][2] At least 20 AKAPs have been cloned. [3] .

A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....

As the name says, “Ayuda sa Kapos ang Kita Program” (AKAP) provides financial aid to minimum wage earners falling under the low-income category, who are severely affected by rising inflation. The main legal basis of AKAP is the “General Appropriations Act of 2024, Special Provision No.3, DSWD Budget,” which authorized the funding for the program.

2004年12月1日 · Here, we discuss two emerging principles in AKAP signalling: the combinatorial assembly of different enzymes on the same AKAP backbone; and the dynamic reorganization of AKAP complexes. cAMP...

Department of Social Welfare and Development (DSWD) Secretary Gatchalian has reiterated that the funding for the Ayuda para sa Kapos ang Kita Program (AKAP) and Assistance to Individuals in Crisis Situation (AICs) are sourced solely from the agency’s approved budget.

1 天前 · The revised AKAP guidelines, jointly prepared by the National Economic Development Authority (NEDA), Department of Labor and Employment (DOLE), and the DSWD, is a requirement set by President Ferdinand R. Marcos Jr as conveyed in his veto message during the signing of the General Appropriations Act (GAA) 2025 last December 30.

3 天之前 · It also barred the presence of elective officials or candidates during the distribution of cash grants under the AKAP, AICS and 4Ps programs. To uphold transparency, the poll body recommended that ...

1 天前 · The Department of Social Welfare and Development (DSWD) is set to implement the revised and stricter guidelines of the Ayuda Para sa Kapos ang Kita Program (AKAP), a senior official said.. DSWD spokesperson Assistant Secretary Irene Dumlao said the revised guidelines will ensure that systems are fine-tuned to prevent the program from being used for political purposes during the campaign period ...

2 天之前 · STRICTER GUIDELINES. Hundreds of beneficiaries queue up for the Ayuda sa Kapos ang Kita Program (AKAP) in Davao City on Sept. 4, 2024. The Department of Social Welfare and Development on Thursday (March 20, 2025) assured that the revised and stricter guidelines for AKAP implementation are fine-tuned to prevent it from being used for political purposes during the campaign period and guarantee ...