A型激酶锚定蛋白及其复合物结构与功能
A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信 …
AKAPs: from structure to function: Trends in Cell Biology
1999年6月1日 · Neutron and x-ray scattering experiments have defined the quaternary structure of the PKA holoenzyme as an extended antiparallel dumbbell, where the bar is formed by the …
AKAP150-anchored PKA regulates synaptic transmission and
2024年3月20日 · Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic …
A-kinase-anchoring protein 1 (dAKAP1)-based signaling …
2020年7月7日 · Dual-specificity protein kinase A anchoring protein 1 (dAKAP1) is a multivalent binding protein that targets protein kinase A (PKA), RNAs, and other signaling enzymes to the …
A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate
2016年11月30日 · AKAP4 (also named AKAP82) is a one of the major components (~50%) of the sperm fibrous sheath, a structure known to be involved in sperm motility. AKAP4 has a …
Dual specificity A-kinase anchoring proteins (AKAPs) contain an ...
In this study we show that dual specificity AKAPs contain an additional PKA binding determinant called the RI Specifier Region (RISR). A variety of protein interaction assays and …
A-kinase anchoring protein 1 (AKAP1) and its role in some ...
2020年1月1日 · A-kinase anchoring proteins (AKAPs) play crucial roles in regulating compartmentalized multi-protein signaling networks related to PKA-mediated phosphorylation. …
Cypher/ZASP Is a Novel A-kinase Anchoring Protein - PMC
2013年10月11日 · Here we provided new evidence that Cypher/ZASP is a typical type II AKAP, which tethers PKA and Ser/Thr phosphatase CaN to their specific substrates, such as LTCC, …
A-Kinase Anchoring Proteins (AKAPs) | SpringerLink
2022年1月1日 · AKAP-PKA interactions play a role in a variety of cellular processes including β-adrenoceptor-dependent regulation of cardiac myocyte contraction or vasopressin-mediated …
AKAP signaling complexes: pointing towards the next generation …
AKAPs streamline signal transduction by localizing enzymes with their substrates. AKAPs coordinate aspects of mitosis and cancer progression. AKAP-mediated signaling is implicated …