A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....

The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. [1][2] At least 20 AKAPs have been cloned. [3] .

A deeper understanding of PKA-R engagement at AKAP complexes will be critical for understanding the roles of the individual roles of each PKA-R isoform in signaling and disease. This study helps to further define parameters for isoform selectivity and understanding constraints for defining how selectivity may be reversed.

1999年6月1日 · Recent structural data indicate that there is a single region of multiple contact sites between the RII subunit dimer and the AKAP, which presumably accounts for the high-affinity interaction. Functionally, this suggests that the AKAP–PKA complex is likely to be a constitutive interaction in cells and not subject to regulation.

Extensive research indicates that AKAPs, which bind and sequester PKA to specific subcellular locations, also nucleate multicomponent protein signaling complexes. Thus, AKAPs are central mediators of crosstalk and integration of cAMP/PKA signaling with other signaling pathways.

Subcellular compartmentalization of protein kinases and phosphatases through their interaction with A-kinase anchoring proteins (AKAPs) provides a mechanism to control signal transduction events at specific sites within the cell.

AKAP-Lbc is a homo-oligomeric Rho-selective guanine nuclear exchange factor (Rho-GEF) that binds Gα 12/13, inducing Rho activity and stress fiber formation in lysophosphatidic acid-stimulated fibroblasts [76, 77]. One target for AKAP-Lbc activated Rho is PKNα, which in turn regulates a MLTK, MKK3 and p38α cascade associated with the scaffold .

Department of Social Welfare and Development (DSWD) Secretary Gatchalian has reiterated that the funding for the Ayuda para sa Kapos ang Kita Program (AKAP) and Assistance to Individuals in Crisis Situation (AICs) are sourced solely from the agency’s approved budget.

2024年12月20日 · The Department of Social Welfare and Development (DSWD) has simplified the guidelines for the target beneficiaries under the Ayuda sa Kapos ang Kita Program (AKAP), which include low-income and minimum-wage earners.

In cAMP-regulated signaling, localization of signaling complexes around AKAP scaffolds is a key element in controlling and regulating intracellular communication. Here, using chemical proteomics, we discovered a novel AKAP, termed smAKAP, which specifically and tightly targets PKA-RI to the inside of the plasma membrane.