The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. [1][2] At least 20 AKAPs have been cloned. [3] .

2004年12月1日 · Here, we discuss two emerging principles in AKAP signalling: the combinatorial assembly of different enzymes on the same AKAP backbone; and the dynamic reorganization of AKAP complexes. cAMP...

AKAPs are a diverse group of molecules that function as cell signaling scaffolds. Specifically, AKAPs dynamically organize and juxtapose protein kinase A (PKA) with specific substrates and other signaling machinery at specific cellular locales.

A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....

2022年1月1日 · A-kinase anchoring protein (AKAP) interaction with cAMP-dependent protein kinase (PKA). The unifying characteristic of canonical AKAPs is the presence of a structurally conserved amphipathic binding helix (orange) which binds in a hydrophobic cleft created by the docking and dimerization (D/D) domains of the regulatory (R) subunits of PKA.

2020年12月1日 · Protein kinase A (PKA) is a versatile and spatially restricted cell signaling enzyme. A‐kinase anchoring proteins (AKAPs) define which substrates have access to PKA. Local signaling islands shape the cellular role of PKA and other AKAP-associated enzymes.

2024年12月24日 · AKAP9 (A-Kinase Anchoring Protein 9) is a Protein Coding gene. Diseases associated with AKAP9 include Long Qt Syndrome 11 and Long Qt Syndrome 1. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and Activation of cAMP-Dependent PKA.

1. What is AKAP? “AKAP” stands for “Ayuda sa Kapos ang Kita Program,” a program that provides financial assistance to low-income, minimum wage earners who are severely affected by rising inflation. 2. Who are its target beneficiaries? The target beneficiaries of the program are individuals whose income does not exceed the statutory ...

AKAPs streamline signal transduction by localizing enzymes with their substrates. AKAPs coordinate aspects of mitosis and cancer progression. AKAP-mediated signaling is implicated in onset and progression of cardiovascular disease. Selected AKAPs may …

1999年6月1日 · The four helices of the RIIα (1–45) dimer are indicated in blue. The upper two helices are predicted to form contacts with the AKAP; the lower two mediate dimerization. The backbone ribbon of the AKAP (Ht31) peptide, shown in yellow, has been modelled to fit into its putative binding site on RII.