
Identification of kidney injury–released circulating osteopontin as ...
2022年2月25日 · Our studies identify kidney tubule cell–released circulating osteopontin (OPN) as a key causal mediator of AKI-induced remote ALI with respiratory failure (AKI-ALI). Aiming at …
住院成人急性肾损伤患者中急性肝损伤的发生率、危险因素和预后
该研究描述了AKI-ALI患者的临床特征和预后。 研究对象包括 2000 年至 2021 年期间在全国 19 家医疗中心住院的 18-99 岁、血清肌酐和肝脏检测结果完整的患者。
Molecular mechanisms of kidney crosstalk with distant organs
2022年11月24日 · Acute kidney injury (AKI) can induce secondary organ complications, including acute lung injury (ALI). A key study conducted in 2022 investigated the mechanism of...
Incidence, risk factors, and outcomes of acute liver injury in ...
This study highlights the association between AKI-ALI and a significantly increased risk of mortality. It suggests that dynamic monitoring of liver function is essential, particularly in …
自噬抑制急性肾损伤诱导急性肺损伤的分子机制
2024年6月4日 · 摘要: 目的 探讨自噬在急性肾损伤(AKI)诱导急性肺损伤(ALI)中的调节作用。 方法 选取48只雄性Sprague-Dawley大鼠,按照随机数字表法分为假手术(sham)组、缺 …
Neutrophil Elastase Contributes to Acute Lung Injury Induced by ...
Neutrophil elastase (NE) is a key enzyme for tissue injury caused by activated neutrophils, such as occurs in ALI. Therefore, this study investigated the role of NE in AKI-induced ALI using a …
Phe-Leu-Ala-Pro 肽通过减轻氧化应激和炎症对 CCl4 引起的急性肝 …
Acute liver injury (ALI) and acute kidney injury (AKI) are significantly affected by the antioxidant status. In the present study, the protective effect and mechanism of the collagen peptide Phe …
Regulation of the autophagy plays an important role in acute …
This study aimed to investigate the regulatory role of autophagy in acute kidney injury (AKI) induced acute lung injury (ALI). The male Sprague–Dawley rats were divided into four groups: …
Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms
Acute kidney injury (AKI) is becoming a public health problem worldwide. AKI is usually considered a complication of lung, heart, liver, gut, and brain disease, but recent findings have …
Acute Kidney Injury: Definition, Pathophysiology and Clinical ...
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the outcome in a significant number of hospitalised patients. Recent advances in clinical and basic …