Background: Acute kidney injury (AKI) is a frequent complication in patients with muscle-invasive bladder cancer (MIBC) who undergo radical cystectomy (RC). Previous studies have reported that AKI during cancer treatment was associated with poor oncological outcomes in …

Background: Acute Kidney Injury (AKI) in patients with COVID-19 infection is associated with poor clinical outcomes. We examined outcomes (hemodialysis, mechanical ventilation, ICU admission and death) in cancer patients with normal estimated glomerular filtration rate (eGFR) treated in a tertiary referral center with COVID-19 infection, who ...

However, the combination of cytotoxic T lymphocyte antigen-4 and PD-1 inhibitors, used to induce a more durable response in cancers such as non–small cell lung cancer, melanoma, or renal cell carcinoma, carries a higher risk of ICI-induced AKI (∼5%) due to the blockade of 2 different checkpoint pathways. 6, 10, 11, 12 The most recently ...

2022年6月2日 · AKI was defined by a rise in the concentration of serum creatinine as per Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A multivariable regression model was used to identify predictors of AKI while accounting for the competing risk of death.

In this study we utilize the National Inpatient Sample (NIS) to understand the effect of acute kidney injury (AKI) on inpatient mortality in multiple myeloma patients. Methods: This is a retrospective study utilizing the data obtained from the NIS for the year 2018.

2019年5月26日 · AKI may occur due to direct injury from primary cancer, nephrotoxic effects of chemotherapy, hematopoietic stem-cell transplantation or following comorbidities like sepsis and metabolic disturbance. AKI is associated with prolonged hospital stay, high healthcare cost and increased mortality in critically ill patients.

Wenxin Xu presented a post-hoc analysis of CheckMate 214 evaluating circulating kidney injury marker-1 as a prognostic and predictive biomarker in advanced renal cell carcinoma (RCC). CheckMate 214 demonstrated that the combination of nivolumab + ipilimumab has superior overall survival and durable responses, compared to sunitinib, with 8 years ...

2023年1月28日 · ASCO guidelines recommend treating patients empirically with steroids when suspicion of ICI-related AKI is high and no other obvious causes of AKI have been found. Kidney biopsy should be considered only if the AKI is refractory to …

Primary endpoint was acute kidney injury (AKI), defined as increase in serum creatinine by > 0.3 mg/dL or ≥ 50% from baseline. Results: 206 patients were selected with most common diagnoses of melanoma (81%) or NSCLC (12%). Most patients (79%) also had stage 4 disease.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment since their introduction ∼15 years ago. However, these monoclonal antibodies are associated with immune-related adverse events that can also affect the kidney, resulting in acute kidney injury (AKI), which is most commonly due to acute tubulointerstitial nephritis (ATIN).