Acute kidney injury (AKI), in contrast, is defined as a kidney disease with rapid loss of renal function. While previously thought to be two separate syndromes, AKI and CKD have been recognized to be closely associated or inter-connected by both clinical and experimental studies in the last decade 4 – 6.

In this review we will discuss functions of the kidney implicated in AKI and CKD, and examine the clinical and experimental evidence for their role in determining levels of acute renal injury and adaptive vs maladaptive renal repair.

There is increasing recognition that acute kidney injury (AKI) and chronic kidney disease (CKD) are closely linked and likely promote one another. Underlying CKD is now recognized as a clear risk factor for AKI, as both decreased glomerular filtration rate (GFR) and increased proteinuria have each been shown to be strongly associated with AKI.

2024年4月8日 · An acute kidney injury (AKI) is caused by a rapid deterioration in kidney function. The pathophysiology of AKI is separated into three main causes: Pre-renal: decreased blood supply resulting in decreased GFR; Renal: damage to the nephron impairing the reabsorption capacity; Post-renal: increased hydrostatic pressure resulting in reduced GFR

Kidney Disease Improving Global Outcomes (KDIGO) guidelines address the definition, classification, and management of acute kidney injury (AKI) and chronic kidney disease (CKD). In practice, some clinical presentations of acute kidney diseases and disorders (AKD) do not meet the criteria for AKI or …

2021年7月15日 · Acute kidney injury (AKI) describes a sudden loss of kidney function that is determined on the basis of increased serum creatinine levels (a marker of kidney...

2024年9月19日 · Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as interconnected conditions with overlapping pathophysiological mechanisms. This review examines the transition from AKI to CKD, focusing on the molecular mechanisms, animal models, and biomarkers essential for u …

2021年1月8日 · 急性肾损伤(Acute Kidney Injury, AKI)向慢性肾脏病(Chronic Kidney Disease, CKD)的进展过程严重影响肾脏预后及患者生存质量，是目前研究热点之一，其中细胞周期停滞是 AKI 向 CKD 进展中一个重要的致病机制。

该项研究应用单侧肾脏缺血再灌注所致的AKI to CKD小鼠模型，通过单细胞测序和空间转录组联合分析，深度解析了AKI小鼠肾脏在由急性损伤向慢性病变转化（AtoC）的过程中，肾脏单核巨噬细胞动态变化图谱，首次发现了参与细胞外基质重塑的关键巨噬细胞（EAMs）亚型及其调控分子机制，可能为防治AKI向CKD转变提供新的药物治疗靶点。...

2017年10月27日 · 慢性肾脏疾病（CKD）的特征为肾功能逐渐减退，持续数月至数年；而急性肾损伤（AKI）则是肾功能迅速下降。 过去，人们认为CKD与AKI是两个完全独立的临床综合征，但近10年来我们发现，AKI与CKD密切相关、相互影响。 一方面，AKI可促进CKD的发生和发展；另一方面，CKD患者又是AKI的易发人群。 本文就AKI与CKD的相互关系以及CKD患者AKI预后差的潜在机制进行简要概述。 虽然目前AKI与CKD的关系尚具争议，但最新的流行病学和实验研究表 …