Underlying CKD is now recognized as a clear risk factor for AKI, as both decreased glomerular filtration rate (GFR) and increased proteinuria have each been shown to be strongly associated with AKI. A growing body of literature also provides …

Nov 25, 2023 · Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in kidney function, as measured by glomerular filtration rate (GFR).[1][2][3] However, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine (Cr) levels may be within the normal range, and the only sign of ...

With improved sample size, assessment criteria and length of follow-up there are now strong data in support of three findings that: 1) pre-existing CKD is a major risk factor for the development of AKI (8-10); 2) patients with CKD who develop AKI often recover incompletely and experience worsened subsequent renal deterioration (8, 11, 12); and ...

Dec 1, 2019 · Acute kidney injury is a clinical syndrome characterized by a rapid decline in glomerular filtration rate and resultant accumulation of metabolic waste products....

急性肾损伤（acute kidney injury，AKI）以往称为急性肾衰竭（acute renal failure，ARF），是指由多种病因引起的 肾功能快速下降而出现的临床综合征。 慢性肾衰竭（chronic renal failure，CRF）为各种慢性肾脏病…

Jan 17, 2019 · Patients with chronic kidney disease (CKD), as evidenced by a low eGFR or presence of proteinuria, are at higher risk for developing AKI, a condition known as acute on chronic renal failure...

Dec 15, 2015 · 2014 年，急性透析质量倡议（ADQI）提出急性肾损伤（AKI）的 RIFLE 诊断标准，分为肾损伤危险、肾损伤、肾衰竭、肾功能丧失、终末期肾衰竭。 此后该标准重新定义为 3 期。 2012 年 KDIGO 临床实践指南对此进行了修正。 目前的 AKI 定义及分类只包含了功能变化：血肌酐和尿量的变化，而 CKD 的定义包括了结构（蛋白尿）和功能（eGFR）的变化这两项。 既定的 AKI、CKD 的定义和分类广泛应用于临床工作、研究和公共健康，促进了临床医师对肾脏病的 …

The currently widespread AKI classification was developed by the Kidney Disease Improving Global Outcomes (KDIGO) work group in 2012 and defines AKI as an increase in the serum creatinine (SCr) level to at least 0.3 mg/dL within 48 h, an increase in SCr to more than 1.5 times the baseline (which is known or presumed to have occurred within the ...

Apr 8, 2024 · Acute kidney injury (AKI) An acute kidney injury (AKI) is caused by a rapid deterioration in kidney function. The pathophysiology of AKI is separated into three main causes: Pre-renal: decreased blood supply resulting in decreased GFR; Renal: damage to the nephron impairing the reabsorption capacity

Jan 10, 2023 · Acute renal failure refers to short-term issues with kidney function. Doctors or healthcare professionals now use the term acute kidney injury (AKI) more often. Chronic renal...