Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide …

Genetic factors have been proposed as potentially responsible for the susceptibility and severity of AKI, explaining why only particular patients are more prone to AKI and why different …

Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) …

2024年12月5日 · We hypothesize that the genetic pathway behind S-AKI has overlapping mechanisms with key differences based upon the specific subtype of acute kidney injury (AKI). …

A meta-analysis using expression-based GWAS identified 46 upregulated and 1 downregulated genes, of which 26 (55%) were previously well known to be associated with AKI, including …

2024年8月1日 · This makes using GWAS the most tractable approach from a population health perspective to study a common syndrome like AKI, as the initial method of choice. AKI affects …

2024年8月1日 · We sought to identify genetic loci associated with AKI among patients with hospitalized AKI. We conducted a large GWAS meta-analysis of persistent AKI among …

2023年6月5日 · We identified the precise cell types that express candidate genes associated with AKI in ASSESS-AKI and the degree to which these genes were differentially expressed in AKI …

2023年7月1日 · AKI is a heterogeneous clinical syndrome with various underlying risk factors, etiologies, and pathophysiology that may limit the identification of genetic variants. Although …

We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estimated the heritable component of AKI in patients who …