2022年2月16日 · In this Review, we summarize the state-of-the art of model development for AKI due to tubular injury, focusing on the translatability of discoveries using human kidney organoids, zebrafish,...

2025年1月2日 · Here we show a simple, real-time, interpretable AKI prediction model for general hospitalized patients developed from a large tertiary hospital in China, which has been validated across five...

2012年12月1日 · Renal ischemia-reperfusion leads to acute kidney injury (AKI), a major kidney disease associated with an increasing prevalence and high mortality rates. A variety of experimental models, both in vitro and in vivo, have been used to study the pathogenic mechanisms of ischemic AKI and to test renoprot …

3 天之前 · This study aimed to develop a machine learning (ML) model for predicting the risk of acute kidney injury (AKI) in diabetic patients with heart failure (HF) during hospitalization. Using data from ...

2024年2月1日 · In this study, we aimed to develop and validate explainable ML models for early and accurate prediction of AKI in critically ill children in a multicenter prospective cohort, elucidate feature importance and explain the model via the SHAP method, and determine the prognostic implications of the final model in the subgrouping of critically ill ch...

本文将主要从药物诱导、单侧输尿管结扎术、缺血再灌注、5 / 6 肾切除术及感染诱导等五种造模方式,分类讨论和总结各种 AKI 动物模型的构建方法与研究现状,并从病理机制探讨相应诱导方式的优缺点及其对应的临床 AKI 类型,为 AKI 动物模型的标准化奠定基础,同时,为肾疾病的体内研究提供理论依据与实验基础。 Acute kidney injury (AKI) is a common disease in clinical practice, and its incidence is increasing yearly along with a high mortality rate.

2021年5月14日 · Some of the mouse models of AKI are renal pedicle clamping (ischemia reperfusion injury), Cisplatin induced nephrotoxicity, sepsis (LPS, cecal slurry, and cecal ligation and puncture), folic acid, and rhabdomyolysis. In this chapter we describe in detail the protocols that are used in our laboratories. 1. Introduction.

2025年3月24日 · In a cisplatin-induced AKI model, Ullah et al. found that EVs could inhibit HSP70/90, reducing the expression of NLRP3 and downstream proinflammatory cytokines. As a result, EVs were able to alleviate AKI. Pulsed-focused ultrasound (pFUS) can enhance the ability of EVs to treat AKI . Further studies have found that the main molecular mechanisms ...

Areas under the receiver operating characteristic curves (AUCs) were used to compare model discrimination and pooled using a random-effects model. Results: Of the 4816 articles initially identified and screened, 95 were included representing 3.8 million admissions. The KDIGO-AKI criteria were the most frequently used to define AKI (72%).

2024年9月1日 · Sepsis-induced acute kidney injury (S-AKI) is one of the most serious life-threatening complications of sepsis. The pathogenesis of S-AKI is complex and there is no effective specific treatment. Therefore, it is crucial to choose suitable preclinical models that are highly similar to human S-AKI to study the pathogenesis and drug treatment.