Members of the AKR7 family can be found in several species. For example AKR7A2 and AKR7A3 are found in humans, AKR7A1 and AKR7A4 are found in rats, and AKR7A5 is found in mice. The purpose of the AKR7 family is typically to reduce aldehyde to alcohol, however some do have more specific functions.

2024年12月24日 · AKR7A2 (Aldo-Keto Reductase Family 7 Member A2) is a Protein Coding gene. Diseases associated with AKR7A2 include Gamma-Amino Butyric Acid Metabolism Disorder and Developmental Dysplasia Of The Hip 1. Among its related pathways are Metapathway biotransformation Phase I and II and Metabolism.

2024年12月24日 · AKR7L (Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with AKR7L include Gastric Cancer. Among its related pathways are Aflatoxin activation and detoxification and Metapathway biotransformation Phase I and II. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity.

Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. [5][6] Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones. [supplied by OMIM] [6] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Aldo-keto reductases (AKRs) are phase I metabolising enzymes that catalyse the reduced nicotinamide adenine dinucleotide (phosphate) (NAD (P)H)-dependent reduction of carbonyl groups to yield primary and secondary alcohols on a wide range of substrates, including aliphatic and aromatic aldehydes and ketones, ketoprostaglan-dins, ketosteroids and...

醛酮还原酶家族 7 成员 a2： 该基因编码的蛋白属于参与醛酮解毒的醛/酮还原酶 (akr) 超家族和 akr7 家族。 AKR7 家族由 3 个基因组成，它们以簇形式存在于 1 号染色体的 p 臂上。

Aflatoxin B (1) aldehyde reductase (AKR7A2) was confirmed to be only highly expressed in pancreatic cancer, not in normal adjacent pancreas and benign tumors. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones.

1998年5月15日 · This novel human aldo-keto reductase (AKR) has been cloned from a liver cDNA library, and together with the rat protein, establishes the AKR7 family of the AKR superfamily. Unlike its rat homologue, human AFAR (hAFAR) appears to be constitutively expressed in human liver, and is widely expressed in extrahepatic tissues.

Aflatoxin reductases (AKR7) have a sequence of 4 small α-helixes in place of the long loop between β7 and α7 . In addition AKR7 proteins do not have a β-hairpin structure at the bottom of the barrel. An additional variable loop in AKRs is between β6 and α4 (loop A).

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1.