FGFR：信号通路与靶向药物 - 知乎
FGFR是一类具有细胞内酪氨酸激酶结构域的跨膜受体家族，与FGF共同构成 FGF/FGFR信号通路，参与细胞发育、分化、存活、迁移、血管生成和致癌过程。
The Complexity and Significance of Fibroblast Growth Factor (FGF …
2024年12月30日 · In this review, we discuss the mechanisms of action of FGFs and FGFRs, as well as how the dysregulation of FGF signaling contributes to cancer in various tumor types. …
了不起的成纤维细胞生长因子 (FGF)家族 - 知乎
成纤维细胞生长因子FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中，FGF家族包括23种多肽，它 …
FGF19( 啮齿动物中FGF15) 是内分泌FGF家族的成员之一,属于肠道激素,参与调节胆汁酸、葡萄糖和脂质代谢等,维持全身稳态。 FGF19/15对多种慢性疾病具有治疗潜力,包括肥胖症、糖尿病 …
FGF Receptors: Cancer Biology and Therapeutics - Katoh - 2014 ...
Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as stemness, proliferation, anti-apoptosis, drug resistance, and angiogenesis. Here, FGF signaling network, …
Fibroblast growth factors (FGFs) in cancer: FGF traps as a new ...
Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells. Thus, they …
FGFs成纤维细胞生长因子及其受体那些事儿 - 知乎
FGF通过与 成纤维细胞生长因子受体 （FGFR）介导的信号轴刺激或维持代谢、组织稳态和发育所需的特定细胞功能，主要调节细胞增殖，分化，存活，迁移和代谢。
Decoding FGF/FGFR Signaling: Insights into Biological Functions …
2024年12月18日 · This review provides a comprehensive overview of FGF-FGFR signaling pathways while highlighting their complex regulatory mechanisms and interconnections with …
Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR …
Seven patients with FGF/FGFR amplification and no alterations in the PI3K/AKT/mTOR pathway received an inhibitor of this pathway and were evaluable for a response and one (14%) …
Nature：温州医科大学李校堃/陈高帜团队发现FGF信号激活全新范 …
2023年6月8日 · 该研究揭示了Klotho蛋白和HS作为共受体协同介导内分泌FGF结合FGFR形成不对称1:2 FGF–FGFR二聚体从而激活下游信号通路的分子机制。 该研究首次清晰的展示了Klotho …
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