Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2 responsible for phosphorylation of Akt at Ser473 has been identified as mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor ...

AKT is a serine/threonine kinase and it participates in the key role of the PI3K signaling pathway. Phosphatidylinositol-3 kinase (PI3K) is the key regulator of AKT activation. The recruitment of inactive AKT protein to PIP3-rich areas of the plasma membrane results in a conformational change that exposes the activation loop of AKT.

2012年12月1日 · Akt is a 56-kDa member of the AGC serine/threonine protein kinase family, discovered in 1991 [1], [2]. In mammals, there are three genes, located on different chromosomes, encoding for Akt1/α, Akt2/β, and Akt3/γ. While Akt1 and Akt2 are ubiquitously expressed [3], Akt3 is found predominantly in brain, kidney, and heart [4].

2024年11月29日 · Akt, also known as protein kinase B (PKB), is a 57-kDa integral kinase and signaling node that belongs to the protein kinase A, kinase G, and kinase C (AGC) superfamily of serine/threonine kinases, which includes the ribosomal S6 protein kinase and serum-glucocorticoid regulated kinases (SGK) Under conditions of homeostasis, Akt responds to ...

丝氨酸-苏氨酸激酶 Akt（也称为蛋白激酶 B（PKB））在广泛影响的信号网络中起着关键作用。Akt 激活通过下游靶标和相互作用伙伴产生多种细胞内反应，从而成为细胞信号传导通路的主开关。Akt 与癌症、糖尿病和神经变性等多种疾病有关。

Explore the Akt pathway that mediates apoptosis and cell proliferation. Find antibodies to detect target proteins, including Akt, p70 S6K, CREB, and p53.

Since its initial discovery as a proto-oncogene, the serine/threonine kinase Akt (also known as protein kinase B or PKB) has become a major focus of attention because of its critical regulatory role in diverse cellular processes, including cancer progression and insulin metabolism.

探索介导细胞凋亡和细胞增殖的 Akt 通路。查找检测靶蛋白的抗体，包括 Akt、p70 S6K、CREB 和 p53。