2024年12月24日 · AKT1S1 (AKT1 Substrate 1) is a Protein Coding gene. Diseases associated with AKT1S1 include Breast Intraductal Papillomatosis and Renal Cell Carcinoma. Among its related pathways are PIP3 activates AKT signaling and MTOR signalling.

AKT1S1 is a proline-rich substrate of Akt (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

2016年2月15日 · Phosphorylation of S202/203 of AKT1S1 by PKM2 released AKT1S1 from raptor and facilitated its binding to 14-3-3, resulted in hormonal- and nutrient-signals independent activation of mTORC1...

"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".

2025年1月4日 · AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008] Expression

2025年2月8日 · Supporting this idea, we identified a downstream target of the TGFb-miR-96 signaling pathway to be AKT1S1 mRNA, whose translated protein is a negative regulator of mTOR kinase. This review discusses the role of PRAS40 and possible feedback mechanisms, and alterations in AKT/PRAS40/mTOR signaling that …

akt1s1 Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by AKT1S1 gene. Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids.

Akt1S1 protects neurons against cell death following spinal cord injury (Saito et al., 2004). Overexpression of AKT1S1 in rats reduces infarct size following cerebral ischemia (Saito et al., 2006; Yu et al., 2008).

AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

Orthologous to human AKT1S1 (Akt1 substrate 1). [provided by Alliance of Genome Resources, Apr 2022]