Harmine (7-methoxy-1-methyl-9H-pyrido [3, 4-b]indole) is a tricyclic beta-carboline alkaloid that was originally isolated from seeds of Peganum harmala in 1847. Harmine has been …

Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and Banisteriopsis caapi. [3] Harmine reversibly inhibits monoamine …

2021年3月30日 · Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities, including antioxidant, anti-inflammatory, …

2015年3月9日 · Using three different mouse and human islet in vivo –based models, we show that harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic …

2025年3月2日 · Harmine, a tricyclic β-carboline alkaloid isolated from the seeds of Peganum harmala L., has emerged as a promising therapeutic candidate owing to its multifaceted …

2024年10月30日 · Harmine is a naturally occurring heterocyclic compound belonging to the β-carboline alkaloid class, found in various plants, some animals, insects, and marine …

2024年8月22日 · 生物活性： Harmine 是一种天然的双特异性酪氨酸磷酸化调节激酶 (DYRK) 抑制剂，具有抗癌和抗炎活性。 Harmine 对 5-HT2A 血清素受体 具有高亲和力， Ki 为 397 nM [1] …

2024年3月7日 · 本文阐述了 Harmine 是一种有前途的心脏肥大治疗剂，独立于血压调节，通过抑制 NF-κB 磷酸化和病理性心室重塑中刺激的炎性细胞因子可缓解心脏肥大。

2020年11月18日 · Harmine (7-methoxy-1-methyl-9H-pyrido [3,4-b] indole) (Fig. 1) is a β-carboline alkaloid with broad-spectrum anti-inflammatory and antitumor activities. In recent years, …

By screening a library of up to 1040 FDA approved compounds and natural products, we identified harmine, a naturally occurring beta-carboline alkaloid, as one of the top hits for turning on the …