2000年10月13日 · Recent randomized controlled trial results indicate that, at least in certain forms of fluid imbalance, albumin is effective in significantly reducing morbidity and mortality. Much further investigation is needed, however, to determine the effects of colloid administration on clinically relevant outcomes in a broad range of critically ill patients.

2004年8月20日 · Intravascular fluid therapy is a common critical care intervention. However, the optimal type of resuscitation fluid, crystalloid or colloid, remains controversial. Despite the many theoretical benefits of human albumin administration in critically ill patients, there has been little evidence to support its widespread clinical use. Previous systematic reviews have led to conflicting results ...

2014年1月9日 · The meta-analyzed data suggest that patients with ARDS may be favored by albumin as compared to crystalloid solutions. Thus, in our opinion, a large multicenter trial investigating the effects of albumin solutions, or even a synthetic colloid, on lung function and damage in patients suffering from ARDS seems justifiable.

2020年5月5日 · Albumin is the colloid fluid of choice when treating oedematous hypovolemic patients. A comparison between iso-oncotic 4–5% and the hyperoncotic 20% albumin in intensive care patients showed a fluid-sparing effect of the latter preparation [1], which is desirable because oedema impairs wound healing [2] and increases the diffusion distance for oxygen [3]. Burn patients develop severe oedema ...

2014年7月16日 · Albumin solutions have been used worldwide for the treatment of critically ill patients since they became commercially available in the 1940s. However, their use has become the subject of criticism and debate in more recent years. Importantly, all fluid solutions have potential benefits and drawbacks. Large multicenter randomized studies have provided valuable data regarding the safety of ...

2025年3月8日 · Albumin infusions appeared to increase net leakage. This study demonstrated a net positive albumin leakage of 8 ± 10 g over 24 h in ICU patients with suspected sepsis, with a weak early correlation to pro-inflammatory cytokines but no significant link to fluid balance or glycocalyx shedding.

2019年5月28日 · Background Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly. Methods Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a ...

2000年5月15日 · The benefit of albumin administration in the critically ill patient is unproven. Epidemiological evidence suggests that there is an increase in death among patients with burns, hypoalbuminaemia, and hypotension treated with human albumin solution (HAS). In critical illness, hypoalbuminaemia is a result of transcapillary leak, decreased synthesis, large volume body fluid losses and dilution ...

2000年10月13日 · The evidence already reviewed supports the concept that reduction in hydrostatic forces and maintenance of normal colloid osmotic pressure might improve clinical outcomes in ALI patients. This evidence equally suggests that combined diuretic and colloid therapy may benefit ALI patients. Approximately 99% of furosemide in the circulation is bound to albumin, and this binding facilitates ...

2014年11月14日 · Introduction The risk of acute kidney injury (AKI) with the use of albumin-containing fluids compared to starches in the surgical intensive care setting remains uncertain. We evaluated the adjusted risk of AKI associated with colloids following cardiac surgery. Methods We performed a retrospective cohort study of patients undergoing on-pump cardiac surgery in a tertiary care center from 2008 ...