2025年2月25日 · Alcohol consumption is intricately linked to the incidence of esophageal squamous cell carcinoma (ESCC). This study comprehensively investigates the role of alcohol-induced microbial alterations in ESCC progression. A retrospective analysis of 328 patients demonstrated that alcohol consumption markedly increases the risk of ESCC and boosts the expression of the proliferation marker Ki67.

2017年12月8日 · Alcohol drinking among males significantly increased the risk for ESCC (OR = 2.20, 95%CI:1.79~2.70). We observed increasing excess ESCC risks with decreasing age at behavior initiation as well as with increasing duration and intensity of alcohol intake, which were particularly evident among current smokers.

2017年5月26日 · We identify six mutational signatures (E1–E6), and Signature E4 is unique in ESCC linked to alcohol intake and genetic variants in alcohol-metabolizing enzymes. We discover significantly...

2010年12月28日 · Quantification of the association between alcohol drinking and risk of esophageal squamous cell carcinoma (ESCC) is an open issue, particularly among light alcohol drinkers, never-smokers, and Asian populations, in which some high-risk polymorphisms in alcohol metabolizing genes are more prevalent.

2020年8月14日 · Aims: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.

2021年3月6日 · This study investigated the alcohol-related microbiota in the oesophagus to demonstrate that alcohol consumption may be involved in the alteration of both the diversity and composition of oesophageal microbiota of ESCC patients.

To the Editor,. Alcohol consumption is strongly associated with the incidence of esophageal squamous cell carcinoma (ESCC) [1, 2].Recent research has highlighted the close relationship between the esophageal microbiota and esophageal cancer [].A comparative analysis of the microbiota in esophageal paracancerous tissue from alcohol-related and non-alcohol-related ESCC patients revealed a ...

2016年6月6日 · We report the findings of a large retrospective study in a cohort of patients with lymph node-negative esophageal squamous cell carcinoma (ESCC), where in the influence of prediagnosis alcohol consumption on postoperative survival in patients with different grades and stages of ESCC, as well as the mechanism underlying these effects was ...

2024年12月5日 · In this review, we will delve into oesophageal cancers induced by chronic alcohol consumption, which is mainly ESCC, outlining its prevalence, epidemiology, mechanisms of carcinogenesis, pathogenesis, genetic factors, epigenetic modifications of chronic alcohol consumption, diagnosis, treatment, and prognosis.

There is a positive synergistic effect of alcohol and tobacco use for ESCC. The observed combined effect of the two factors is almost double if there were no synergy. Efforts for controlling the burden of ESCC should focus on individuals who use both alcohol and tobacco.