10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene. [5] The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP), and water to tetrahydrofolate, NADPH, and carbon dioxide.

2024年12月24日 · ALDH1L1 (Aldehyde Dehydrogenase 1 Family Member L1) is a Protein Coding gene. Diseases associated with ALDH1L1 include Intellectual Developmental Disorder, Autosomal Recessive 59 and Focal Dermal Hypoplasia. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism.

醛脱氢酶 1 家族成员 L1 (ALDH1L1) 是叶酸代谢中的一种关键酶，因此在细胞代谢和增殖的调节方面起着重要作用。 已在肿瘤中发现 ALDH1L1 下调，导致对癌细胞增殖的抑制减弱。 靶向 ALDH1L1 的抗体标记大脑中星形胶质细胞的细胞浆，可有效染色细胞体和这些细胞的过程。 ALDH1L1 Antibody #34391： 使用 ALDH1L1 (E7D7G) Rabbit mAb (IF Preferred) #34391（绿色）和 GFAP (GA5) Mouse mAb (Alexa Fluor ® 647 Conjugate) #3657（红色）对小鼠海马细 …

2025年2月8日 · ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke. Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.

ALDH1L1 is a prognostic marker in Kidney renal clear cell carcinoma, Thyroid carcinoma

2020年2月10日 · From this study, Aldh1l1, which encodes aldehyde dehydrogenase family 1 member L1 (ALDH1L1), emerged as a pan astrocyte marker and was confirmed with Aldh1l1 -EGFP reporter mice that...

2025年2月8日 · Clinical resource with information about ALDH1L1, Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes., Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects., Genome-wide meta-analysis of homocysteine and methionine metabolism ...

The metabolic enzyme for folate, Aldh1L1, has been shown to be expressed robustly in astrocytes of the brain. It is now well accepted that astrocytes in certain regions of the adult brain also serve as neural stem cells. Here, we examined whether Aldh1L1 is …

该基因编码的蛋白质催化 10-甲酰四氢叶酸、烟酰胺腺嘌呤二核苷酸磷酸 (NADP+) 和水转化为四氢叶酸、NADPH 和二氧化碳。 编码的蛋白质属于醛脱氢酶家族。 该基因功能或表达的丧失与细胞凋亡减少、细胞运动增加和癌症进展有关。 有一个反义转录物在与该基因位点相反的链上重叠。 可变剪接导致多个转录本变体。 [RefSeq 提供，2012 年 6 月]

2025年2月8日 · Gene ID: 107747, updated on 8-Feb-2025. Enables formyltetrahydrofolate dehydrogenase activity. Involved in 10-formyltetrahydrofolate catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ.