Oncogenic EML4-ALK assemblies suppress growth factor ... - Nature
2024年11月2日 · The EML4-ALK oncogene forms cytoplasmic protein condensates that are associated with its oncogenic signaling. Here, the authors demonstrate that these EML4-ALK assemblies also sequester...
Mechanisms of synergistic suppression of ALK-positive lung
2023年6月20日 · EML4-ALK is a chromosomal rearrangement caused by fusion between echinoderm microtubule-associated protein-like 4 (EML4) and ALK, creating constitutively active ALK 14. ALK-positive (ALK +)...
Molecular mechanisms that underpin EML4-ALK driven cancers
2016年1月11日 · ALK signalling is activated in cancer cells through three principal mechanisms: gene fusion events, such as NPM-ALK and EML4-ALK; ALK gene amplification; and activating point mutations such as F1174L in neuroblastoma (Fig. 2b).
RAS-MAPK in ALK targeted therapy resistance - PMC
To identify rational co-targeting strategies to enhance clinical outcomes, we explored the molecular basis of ALK oncogene dependence in ALK gene rearrangement positive (ALK+) lung adenocarcinoma. We discovered that the RAS-RAF-MEK-ERK pathway is the critical downstream pathway necessary for ALK+ tumor cell survival.
NPM-ALK: A Driver of Lymphoma Pathogenesis and a Therapeutic …
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase associated with Anaplastic Large Cell lymphoma (ALCL) through oncogenic translocations mainly NPM-ALK. Chemotherapy is effective in ALK(+) ALCL patients and induces remission rates of ...
Mechanisms of suppression of cell growth by dual inhibition of ALK …
2019年12月11日 · Up front combination of ALK and MEK inhibition has improved the response in a preclinical model of EML4-ALK NSCLC, and in a patient derived acquired resistance cellular model of EML4-ALK...
Activated ALK signals through the ERK–ETV5–RET pathway to …
2018年1月11日 · The downstream signaling pathways of the emblematic NPM–ALK fusion protein that trigger oncogenic transformation have now been deeply studied and three main pathways including the Ras-extracellular signal-regulated kinase (ERK) pathway, the Janus kinase 3 (JAK3)/STAT3 pathway, and the phosphatidylinositol-3-kinase (PI3K)/AKT pathway have been ...
Targeting ALK Rearrangements in NSCLC: Current State of the Art
Anaplastic lymphoma kinase (ALK) alterations in non-small cell lung cancer (NSCLC) can be effectively treated with a variety of ALK-targeted drugs. After the approval of the first-generation ALK inhibitor crizotinib which achieved better results in ...
Role of ERK-BIM and STAT3-survivin signaling pathways in ALK …
2011年4月15日 · ALK inhibitor-induced apoptosis is mediated both by BIM upregulation resulting from inhibition of ERK signaling as well as by survivin downregulation resulting from inhibition of STAT3 signaling in EML4-ALK-positive lung cancer cells.
激活素受体样激酶 | Activin receptor-like kinase (ALK) | MCE
激活素受体样激酶 (alk) 是转化生长因子 β (tgf-β) 超家族的 i 型受体。磷酸化的alk激活多种下游信号转导途径，包括 mapk-erk，pi3k-akt，plcγ，crkl-c3g 和 jak-stat。 - mce 生物医学词典