ALK (D5F3) CDx: an immunohistochemistry assay to identify ALK …
ALK IHC as a standalone test for ALK rearrangements in NSCLC. As discussed above, several lines of evidence support the notion that IHC with the clone D5F3, in particular the ALK (D5F3) …
Revisiting ALK (D5F3) immunohistochemistry: Insights into focal ...
2024年9月10日 · Screening for anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC) is crucial for identifying patients eligible for targeted therapy. The FDA …
以ALK融合基因检测浅谈PCR、IHC和FISH方法的优劣
2018年7月17日 · 目前指南推荐fish检测作为alk融合基因的标准方法，非小细胞肺癌（nsclc）的治疗已进入到个体化治疗的时代。肺癌中alk变异主要为alk基因发生重排与其他基因融合。
An International Interpretation Study Using the ALK IHC Antibody …
Immunohistochemistry (IHC) is a clinically applicable cost-effective test that is sensitive and specific for ALK protein expression. The purpose of this study was to assemble an …
ALK Protein Analysis by IHC Staining after Recent Regulatory …
2016年4月1日 · Recent regulatory changes have allowed the diagnostic use of immunohistochemical (IHC) analysis for the identification of patients with non–small cell lung …
Shifting from Immunohistochemistry to Screen for ALK ... - MDPI
2024年6月14日 · This study investigates the effectiveness of RNA NGS as a reflex test for identifying ALK fusions in NSCLC, with the goal of replacing ALK IHC in the systematic …
An international interpretation study using the ALK IHC ... - PubMed
Immunohistochemistry (IHC) is a clinically applicable cost-effective test that is sensitive and specific for ALK protein expression. The purpose of this study was to assemble an …
浅谈ALK 融合基因检测中IHC与FISH方法孰优孰劣？ - ipathology
2015年12月25日 · 目前分子病理的检测工作中，ALK基因的融合主要有三种方法，荧光定量PCR法（RT-PCR），免疫组化法（IHC）和荧光原位杂交法（FISH）。 以上方法中，因为荧光定 …
Novel selective strategies targeting the BCL-2 family to enhance ...
4 天之前 · For this reason, fluorescence in situ hybridization (FISH) and IHC have been established as the primary methods for the detection of ALK rearrangements, but its accurate …
Interpretation of Anti-ALK Immunohistochemistry Results
In ALK fusion-positive tumors, therefore, all tumor cells are immunostained for the ALK kinase domain in IHC using anti-ALK antibody directed to the kinase domain, when stained …