In organometallic chemistry, organolithium reagents are chemical compounds that contain carbon – lithium (C–Li) bonds. These reagents are important in organic synthesis, and are frequently used to transfer the organic group or the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. [1] .

Alkyllithium compounds interact with organometallic compounds of different metals (MtR′ n), most notably those of Groups I, II, and III, which behave like Lewis acids, to form mixed organometallic compounds, referred to as ‘ate’ complexes, 61 schematically represented in …

Alkyllithium, alkylaluminum, and alkylmagnesium compounds are the most common carbanion reagents in laboratory-scale synthetic chemistry; carbanion character is greatly diminished for the less metallic elements boron and silicon.

2023年11月6日 · Alkyllithium reagents represent one of the most commonly used organometallic compounds. The wide range of applications results mostly from their ability to react as Brønsted bases and as nucleophiles. In this contribution, we took …

2015年11月9日 · In this post we’ll talk about how certain types of organometallic compounds are made – specifically organolithium and Grignard reagents. Quick summary: Let’s start with organolithium reagents because they’re the simplest. Table of Contents. 1. Organolithium Reagents As Carbanions.

Alkyllithium compounds account for important developments in organic synthesis, in many cases they were the starting point for important contributions to the organometallic chemistry of the transition metals.

Alkyllithium compounds are a class of organometallic reagents that contain a carbon-lithium bond. They are highly reactive and commonly used in organic synthesis for carbon-carbon bond formation and other transformations.

2024年7月10日 · Alkyllithiums are both nucleophiles and strong bases, and their chemistry is similar in many respects to that of alkylmagnesium halides. One particularly valuable reaction of alkyllithiums occurs when making lithium diorganocopper compounds, R 2 CuLi, by reaction with copper (I) iodide in diethyl ether as solvent.

2021年1月21日 · This reaction occurred in polydienes such as polybutadiene, high-vinyl polybutadiene, polyisoprene, and natural rubber. The effects of the reaction time, temperature, butyllithium dosage, and alkyllithium species in this reaction were studied in detail.

Density functional theory was used to examine the solvation number and aggregation state of several alkyllithium compounds in clusters with tetrahydrofuran molecules coordinated to each lithium atom.