2023年12月11日 · the world’s first trna platform company, deciphering trna biology and pioneering trna therapeutics to treat thousands of diseases. Alltrna is advancing universal tRNA …

Each mRNA codon is recognized by a particular type of tRNA, which docks to it along a three-nucleotide anticodon, and together they form three complementary base pairs. On the other …

tRNA medicines have the potential to treat all diseases caused by a premature termination or “stop” codon, known as Stop Codon Disease. Alltrna is first engineering tRNA medicines that …

Alltrna's platform uniquely combines internal expertise and proprietary machine learning tools to comb through the vast combinatorial landscape of possible tRNA molecules to engineer tRNA …

2016年1月4日 · Transfer RNAs represent the largest, most ubiquitous class of non-protein coding RNA genes found in all living organisms. The tRNAscan-SE search tool has become the de …

Alltrna has successfully applied machine learning to reveal tRNA’s unique language and design rules. Through this understanding, Alltrna is systematically programming tRNAs to control …

Founded at Flagship Labs in 2018, Alltrna has mapped tRNA biology to systematically design tRNA medicines and encode a completely new, unifying approach to treating both rare and …

2023年3月1日 · For this reason, we developed ALL-tRNAseq, which combines the highly processive MarathonRT and RNA demethylation for the robust assessment of tRNA …

CAMBRIDGE, Mass., May 18, 2023 /PRNewswire/ -- Alltrna, a Flagship Pioneering company unlocking transfer RNA (tRNA) biology and pioneering tRNA therapeutics to regulate the …

2024年5月7日 · Alltrna presents data showing ML-based algorithms can rapidly improve tRNA designs and increase engineered tRNA activity through sequence and chemical modification …