Allopregnanolone is an endogenous inhibitory pregnane neurosteroid. [10] It is made from pregnenolone, and is a positive allosteric modulator of the action of γ-aminobutyric acid (GABA) at GABA A receptor. [10]

Allopregnanolone, a 3α,5α‐progesterone metabolite, acts as a potent allosteric modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with ...

Allopregnanolone is synthesized in the central nervous system either de novo from cholesterol or from steroid hormone precursors like progesterone and pregnenolone. Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone ...

Allopregnanolone (3α-THP) has been one of the most studied progesterone metabolites for decades. 3α-THP and its synthetic analogs have been evaluated as therapeutic agents for pathologies such as anxiety and depression.

2022年1月10日 · Allopregnanolone is a neurosteroid that is a metabolite of progesterone and is synthesized in the central nervous system, adrenal cortex, and gonads (Irwin et al., 2014). It directly binds to and is a potent positive allosteric modulator of GABA-A …

Allopregnanolone is a potent neurosteroid that acts as a positive allosteric modulator of GABA A receptors, playing a crucial role in inhibiting seizures in the brain by enhancing synaptic inhibition.

2020年3月14日 · Changes in brain levels of allopregnanolone during pregnancy and in the postpartum period, or during exposure to protracted stress appear to play a crucial role in the pathophysiology of mood disorders.