2022年1月7日 · In a key study that helped lead to febuxostat’s approval, it was shown that both allopurinol and febuxostat can help people achieve a uric acid level of below 6 mg/dL. Febuxostat helps more people achieve ideal uric acid levels, but it also has more risks.

2022年2月3日 · Allopurinol and febuxostat achieved serum urate goals in patients with gout; allopurinol was noninferior to febuxostat in controlling flares. Similar outcomes were noted in participants...

2020年1月31日 · For treating gout, clinical trials conclude Febuxostat (Uloric) is more effective vs allopurinol (Zyloprim). Unfortunately, the major caveat is the higher number of deaths of gout patients especially ones with heart problems.

2005年12月8日 · Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout.

Compare Allopurinol vs Febuxostat head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

2005年12月8日 · Febuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Similar reductions in gout flares and tophus area occurred in all treatment groups.

2022年2月3日 · CONCLUSIONS Allopurinol and febuxostat achieved serum urate goals in patients with gout; allopurinol was noninferior to febuxostat in controlling flares. Similar outcomes were noted in...

Allopurinol and febuxostat achieved serum urate goals in patients with gout; allopurinol was noninferior to febuxostat in controlling flares. Similar outcomes were noted in participants with stage 3 chronic kidney disease.

Compared with allopurinol, febuxostat was associated with an improved safety outcome of cardiac-related mortality and adverse skin reactions (OR: 0.72, 95% CI: 0.55-0.96, P = 0.02).

2022年9月11日 · From a mechanism of action standpoint, allopurinol and febuxostat are the same. Both are xanthine oxidase inhibitors. Inhibition of the enzyme leads to reduced formation of uric acid and can ultimately help lower uric acid levels and reduce the risk of gout flares.