Alloxan is a toxic glucose analogue, which selectively destroys insulin -producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species. This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans.

Alloxan is a member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups. It has a role as a hyperglycemic agent and a metabolite. It is functionally related to a barbituric acid. Alloxan has been reported in Euglena gracilis with data available.

Jan 1, 2017 · Alloxan is one of the common diabetogenic agents often used to assess the antidiabetic potential of both pure compounds and plant extracts in studies involving diabetes.

Feb 1, 2016 · Alloxan is a thermally stable white solid with an unusual structure. Its formal name is 2,4,5,6 (1 H,3 H)-pyrimidinetetrone, indicating that it has a pyrimidine ring structure with four carbonyl groups. It is freely soluble in water, forming a slightly acidic solution. The solid begins to decompose at 256 ºC.

Sep 28, 2021 · Alloxan is an important toxic glucose analogue used to induce diabetes in lab test animals. Once regarded as a “problem structure,” the condensed-phase structure of anhydrous alloxan has largely been settled, but literature inconsistencies remain for the structure of the typically employed reagent alloxan monohydrate.

Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds. Notably, alloxan is far less expensive and more readily available than streptozotocin. On this ground, one will logically expect a preference for use of alloxan in experimental diabetes studies.

Mar 1, 2018 · In our study, the CGPS treatment could reduce the fasting blood glucose levels and recover the triglycerides (TG), total cholesterol (TC) and glycosylated serum protein (GSP) levels in serum of diabetic mice. Urine samples in normal group, model group and CGPS high dose group were dispersed in the PLS-DA score plots.

纳洛酮为吗啡受体拮抗剂，口服无效，注射给药起效很快。 主要用于阿片类药物过量中毒或用于阿片药成瘾的诊断。 还用于吗啡类复合麻醉药术后，解除呼吸抑制及催醒。 中文名称：纳洛酮. 中文别名： (5α)-3,14-二羟基-17-丙-2-烯-1-基-4,5-环氧吗啡烷-6-酮. 英文名称：naloxone. CAS号：465-65-6. 分子式：C19H21NO4. 分子量：327.374. 精确质量：327.14700. PSA：70.00000. LogP：1.23930. 外观与性状：白色至略灰白色粉末. 密度：1.43 g/cm 3. 熔点：184ºC. 沸 …

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Jan 1, 2021 · Diabetes trials of alloxan monohydrate have been one of the most used diabetes chemicals. The action mechanism in β cells has been thoroughly studied and understood quite well. When given...