The Alu family is a family of repetitive elements in primate genomes, including the human genome. [6] Modern Alu elements are about 300 base pairs long and are therefore classified as short interspersed nuclear elements (SINEs) among the class of repetitive RNA elements.

Alu家族是灵长类基因组特有的含量丰富的短分散重复序列（short interspersed elements，SINEs）在基因组中的拷贝数已经达到了50万，每个拷贝长度约300 bp。 ALU家族：Alu家族每个成员的长度约300bp，每个单位长度中有一个 限制性内切酶 Alu的切点（AG↓CT），Alu可将其切成长130和170bp的两段。 ALU家族具有种特异性，可用于区分不同的哺乳细胞，不同的Alu成员的侧翼重复顺序各不相同，在相近的生物体中Alu家族在结构上存在相 …

2011年12月12日 · Alu elements are primate-specific repeats and comprise 11% of the human genome. They have wide-ranging influences on gene expression. Their contribution to genome evolution, gene regulation and disease is reviewed.

2002年5月1日 · Here, we present an overview of the biology and the impact of Alu repeats — the largest family of mobile elements in the human genome. Discovery and origin of Alu elements. The term...

Alu belong to the SINE family (Short Interspersed Nuclear Elements) of repetitive elements; they emerged 55 millions years ago with the radiation of primates by a fusion of the 5′ and 3′ ends of the 7SL RNA gene, which encodes the RNA moiety of the signal recognition particle (SRP).

The new analysis was based on 562,843 Alu sequences collected from human and aligned against AluSx. New subfamilies ( highlighted with red in the tree ) and existing subfamilies were then re-aligned to AluJo to create the multiple alignment.

In this brief paper, the author will describe the structure of human (Alu) and murine (B1, B2, ID, and B4) retroelements, a broad overview of the contribution of Alu retrotransposition to human diseases, and finally describe in depth a novel role of double-stranded Alu RNAs affecting the progression of age-related macular degeneration (AMD) and ...

2017年2月10日 · In this review we focus on recent advances of how Alu elements are pervasively involved in gene regulation. We discuss the impacts of Alu DNA sequences that are in close proximity to genes, Pol-III-transcribed free Alu RNAs, and Pol-II-transcribed Alu RNAs that are embedded within coding or noncoding RNA transcripts.

The Alu family of short (approximately 300bp)interspersed elements (SINEs) is one of the most successful mobile genetic elements, having arisen to a copy number in excess of 500,000 within primate genomes in the last 65 million years. The proliferation of these elements had …

2016年1月1日 · Alu family refers to 150–300-bp long nucleotide sequence monomers associated head-to-tail, and repeated about 300,000–500,000 times or more in the primate genome. RNA polymerase III transcribes Alu sequences. These nucleotide sequences are cut by the Alu I restriction enzyme (recognition site AG↓CT) and hence the name of these gene families.