2024年6月14日 · When two Alu elements with inverse orientations are positioned in close proximity, their transcription results in the generation of distinct double-stranded RNAs (dsRNAs), known as inverted Alu...

We observed that two Alu elements in inverted orientation within the 3′-UTR of human mRNAs give rise to dsRNA. Although the structures are extensively edited in vivo, the presence of inosine did not affect mRNA export, stability or translatability.

2024年10月3日 · We provide compelling evidence to link the detrimental effect of Alu _Ins to extensive dsRNA structures formed between Alu _Ins and pre-existing intronic Alu sequences, including the restoration of SPINK1 mRNA expression by aligning all three Alu elements in the same orientation.

2023年7月12日，来自中国科学院生物物理研究所的薛愿超团队在Nature杂志在线发表题为Complementary Alu sequences mediate enhancer-promoter selectivity 的文章。该研究基于RIC-seq技术【3, 4】系统构建了涵盖7种人源细胞系的增强子-启动子RNA互作（EPRI）图谱（图1），并首次揭示了 ...

2022年1月19日 · Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with significant pathological consequences.

2022年1月20日 · Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with significant pathological consequences.

2020年11月15日 · We find widespread loss of adenosine-to-inosine editing of Alu RNAs in MS. Unedited Alu RNAs are potent activators of both IFN and NF-κB responses via the dsRNA sensors, RIG-I, and TLR3. Minor editing of highly active Alu elements abrogates the ability to activate both transcriptional responses.

2012年9月1日 · It is possible that long dsRNA structures formed from Alu elements influence gene expression. Here, we report that human mRNAs containing inverted Alu elements are present in the mammalian cytoplasm.

2019年6月1日 · Endogenous Alu and Line double stranded RNAs may be the source of type 1 IFN responses in relapsing remitting multiple sclerosis and possibly other human autoimmune diseases. Various sensors that detect double-stranded RNA, presumably of viral origin, exist in eukaryotic cells and induce IFN-responses.

Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with significant pathological consequences.