In organic chemistry, an amide, [1][2][3] also known as an organic amide or a carboxamide, is a compound with the general formula R−C (=O)−NR′R″, where R, R', and R″ represent any group, typically organyl groups or hydrogen atoms. [4][5] The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bo...

Amidation is one of the most common techniques to graft molecules and polymers to the amine of chitosan. It can be achieved using carboxylic compounds with carbodiimides such as EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) or DCC (dicyclohexyl carbodiimide) coupled with NHS (N-hydroxysulfosuccinimide) to accelerate the ...

write an equation to describe the preparation of an amide from an acid chloride. identify the amide linkage as the basic unit from which all proteins are made, and hence recognize the importance of the amide linkage to biologists and biochemists. write detailed mechanisms for the acidic and basic hydrolysis of amides.

The amidation reaction to produce fatty acid diethanolamide is an important unit process to produce surfactants from renewable sources rather than from petroleum sources. Amidation is a liquid-phase reaction between diethanolamine with a fatty acid methyl ester.

Iodine catalyzes an amidation of tertiary amines with acyl chlorides through oxidative C-N bond cleavage. A broad range of aromatic acyl chlorides and tertiary amines are efficiently converted into amides in good yields under mild conditions. A plausible mechanistic pathway is proposed for this transformation.

2020年4月28日 · This review compiles the most recent efforts towards sustainable approaches that contribute to solving the problems associated with traditional methods. The new routes are based on promising reagents to performed more versatile and efficient amidation reactions.

2023年1月23日 · Carboxylic acid derivatives are a group of functional groups whose chemistry is closely related. The main difference is the presence of an electronegative substituent that can act as a leaving group during nucleophile substitution reactions.

Amidation is the chemical reaction that forms an amide from a carboxylic acid and an amine. This process involves the nucleophilic attack of the amine on the carbonyl carbon of the carboxylic acid, leading to the formation of a covalent bond and the release of water as a byproduct.

An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides proceeded smoothly without any ligand. A wide range of N -alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yields.

2025年4月10日 · Amidation is one of the most frequently executed transformations in synthetic chemistry, and using an electrochemical approach, the current study has demonstrated the synthesis of amides from aldehydes and amines. Mechanistic work indicates that the reaction proceeds via the oxidation of an intermediate hydrazone to generate an acyl diazene as ...