2024年11月15日 · BNZ-111 is as a novel benzimidazole anticancer agent with optimized tubulin potency, improved solubility and pharmacokinetic parameters. Structure to activity relationship of benzimidazole anticancer agents is thoroughly surveyed and …

酰 xiān 胺 àn （英語： Amide）是指 酰基 碳与 胺类 相连的一类化合物， 官能团 可记为R 1 C (=O)NR 2 R 3，其中R 1 、R 2 和R 3 可以是氢原子或有机基团 [1][2]。 酰胺也可以看作是 羧酸 与 氨 或 胺 缩合 形成的有机化合物，是 羧酸衍生物 的一类，简单的酰胺有： 甲酰胺 、 乙酰胺 、 苯甲酰胺 和 N,N -二甲基甲酰胺。 酰胺在自然界中广泛存在，并在科学技术中有重要应用。 蛋白质 中的 肽键 便以酰胺结构相连接。 工业上重要的化工材料，如 尼龙 、 芳纶 、 克维拉 、 特瓦 …

2024年9月1日 · Disrupting tubulin polymerization is a mechanism of action through which BNZ-111 induces anti-cancer activity. BNZ-111 demonstrates in vivo efficacy and potential for overcoming paclitaxel resistance.

2024年9月11日 · Molecular docking study suggests BNZ-111 have a specific binding mode to the β subunit of curved tubulin. BNZ-111 is potent to cancer cells and possesses good drug-like properties as oral drug. Especially, BNZ-111 is not a P-gp substrate and it demonstrates its efficacy over Paclitaxel-resistance tumor in vivo.

This study investigated the potential of the benzimidazole derivative BNZ-111 as a novel treatment strategy for platinum-resistant ovarian cancer. Methods: The human EOC cell lines A2780, HeyA8, SKOV3ip1, A2780-CP20, HeyA8-MDR, and SKOV3-TR were treated with BNZ-111, and cell proliferation, apoptosis, and cell cycle were assessed.

S-(COD OLIGOPEPTIDE-1 SH-OLIGOPEPTIDE-111 SP) AMIDE Substance information. Peptides are linking products of some (oligopeptides, eg 6 = hexapeptide) or many amino acids (then referred to as polypeptides or proteins).

AMIDET® TEC-111 MAIN PROPERTIES APPLICATION BENEFITS · Ethoxylated alkyl monoethanol amide · Based on renewable rapeseed (canola) oil from local production · Renewable carbon content: 70% · Nonionic main emulsifier with corrosion-inhibiting properties · Easy to formulate ·Clear-to-yellowish liquid ·Emulsifier for vegetable oils

AMIDET A-111-P is a solid non-ionic surfactant of vegetable origin – Comamide MEA. It performs increasing foam stability and viscosity when it is combined with normal used anionic surfactants. It is an effective foam booster. Its use allows reducing the quantity of sodium chloride needed to adjust viscosity in the final formula.

AMIDET® TEC 111 is an ethoxylated alkyl mono ethanol amide emulsifier based on rapeseed (canola oil). It is an ideal combination of emulsifying properties and corrosion inhibition. This emulsifier blend is based on natural raw materials to simplify the formulation process.

AMIDET TEC-111, PEG-4 rapeseed amide (PEG-4 canola amide + MEA + TEA + fatty acid), Blend based on amide ethoxylates for metal working fluids industry