2021年6月21日 · 在ca3->ca1突触中，突触后膜上有很多的nmda受体通道和ampa受体通道，尤其是nmda受体通道在ltp和ltd中起了关键作用。 NMDA受体和AMPA受体 现在介绍一下AMPA受体，突触后膜上AMPA受体数量是衡量一个突触强度的重要指标。

2020年9月7日 · We present a network model of AMPAR trafficking for adult hippocampal pyramidal neurons, which reproduces both LTP and LTD.

原位杂交和免疫细胞化学实验表明，ampa 受体主要分布在大脑中。这些受体在 突触可塑性 、兴奋性神经传递、长时程增强（ltp，即突触增强）和长时程抑制（ltd，即突触减弱）中发挥重要作用，并参与学习和记忆的形成14,15,18,26。ampa 受体如此重要也意味着它们 ...

AMPA receptors in LTP and LTD. During LTP (left), GluA1-containing AMPA receptors are inserted into the synaptic surface to maintain synaptic strength, whereas during LTD (right), GluA1-containing AMPA receptors are internalized, leading to synaptic depression. CaN calcineurin; PP1 protein phosphatase 1. GluA1-Containing AMPA Receptors in LTP

突触后谷氨酸门控离子通道允许带正电荷的离子进入突触后细胞，并能进一步被分为AMPA（a-氨基-3-羟基-5-甲基-4-异唑丙酸）受体或NMDA（N-甲基-D-天冬氨酸）受体。 AMPA和 NMDA受体 共同分布于许多突触。 NMDA受体是一种通道型受体，它的通道部分常通过的是Ca2+。 AMPA受体 也是一种通道型受体，它主要负责Na+的通过。 NMDA受体具有两个非同寻常的特点。 首先，由于通道处Mg2+的作用，使得NMDA受体成为电压门控通道。 在静息膜电位状态时，由 …

We have addressed the expression of long-term potentiation (LTP) in hippocampal CA1 by comparing AMPA and NMDA receptor–(AMPAR- and NMDAR-) mediated postsynaptic signals. We find that potentiation of NMDAR-mediated signals accompanies LTP of AMPAR-mediated signals, and is associated with a change in variability implying an increase in quantal ...

2007年2月1日 · Long-term potentiation (LTP) and long-term depression (LTD) are two important forms of bidirectional synaptic plasticity which, while different in molecular mechanisms, can...

2006年4月2日 · Plant et al. now report transient insertion of Ca 2+ -permeable AMPA receptors after LTP induction, and find their activation is required for LTP maintenance. LTP is the prototypical form...

2021年10月1日 · AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This pheno …

2000年3月24日 · These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein. Long-term potentiation (LTP) of synaptic transmission is a well-characterized form of activity-dependent plasticity likely to play important roles in learning and memory ( 1 ).