α-氨基羟甲基恶丙酸（α-amino-3-hydroxy-5-methy1-4-isoxazole propionic acid，AMPA）受体通过与膜蛋白的相互作用，调节突触的可塑性和稳定性，参与LTP的形成。 海人藻酸 （kainic acid， KA）受体作为突触传递LTP的触发点起作用。

2021年5月24日 · AMPA receptors specifically are required for segregating cell fate components during Wnt3a-mediated asymmetric cell division (ACD). Using Wnt-pathway component knockout lines, we determine that Wnt co-receptor Lrp6 has particular functionality over Lrp5 in cytoneme formation, and in facilitating ACD.

2014年2月1日 · We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to: (i) act as potent regulators of hippocampal synapses and impact in learning and memory; (ii) regulate adult neurogenesis; and finally (iii) control AD pathogenesis.

谷氨酸受体主要分为两类，即离子型谷氨酸受体和代谢型谷氨酸受体，其中离子型谷氨酸受体包括四个亚型：NMDA 受体、非 NMDA 受体、AMPA 受体和 kainate 受体。

2022年9月30日 · The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information processing in the brain, and ubiquitination is a key regulator for this biological process. However, the roles of E3 ubiquitin ligases in the regulation of …

2023年3月8日 · However, even though glyphosate and its main metabolite, aminomethylphosphonic acid (AMPA), contaminate the environment and pose threats to humans, their mechanism of toxicity is not well-elucidated. One possible mechanism of action is through the canonical Wnt pathway.

2021年1月17日 · By using super-resolution microscopy in live and fixed hippocampal neurons, we found that Wnt5a modulates the dynamic and localization of AMPARs. Specifically, Wnt5a stabilizes AMPARs in synaptic and extrasynaptic sites. This correlates with an increase in co-localization and interaction between GluA2 and PSD95.

突触后谷氨酸门控离子通道允许带正电荷的离子进入突触后细胞，并能进一步被分为AMPA（a-氨基-3-羟基-5-甲基-4-异唑丙酸）受体或NMDA（N-甲基-D-天冬氨酸）受体。 AMPA和 NMDA受体 共同分布于许多突触。 NMDA受体是一种通道型受体，它的通道部分常通过的是Ca2+。 AMPA受体 也是一种通道型受体，它主要负责Na+的通过。 NMDA受体具有两个非同寻常的特点。 首先，由于通道处Mg2+的作用，使得NMDA受体成为电压门控通道。 在静息膜电位状态时，由 …

2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活化，可分为经典通路（即 Wnt／β-catenin信号通路）和非经典通路（包括Wnt／PCP通路和 Wnt-Ca2+通路）。 2017年5月，美国斯坦福大学医学院的 Roel Nusse 教授和荷兰乌得勒支大学医学中心 Hans Clevers 教授在《Cell》期刊（IF=66.89）上发表题为“ Wnt/b-Catenin Signaling, Disease, and …

2020年8月4日 · AMPA-type glutamate receptors (AMPARs) are key to virtually any aspect of excitatory neurotransmission in the mammalian brain: they drive synapse formation, mediate the excitatory current required for the synaptic point-to-point response and endow synapses with activity-dependent dynamics that are fundamental for memory formation and learning ...