Objective: To provide a comprehensive review of the central nervous system (CNS) involvement in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including the pathogenesis, clinical manifestations, ancillary investigations, ...

2024年8月31日 · Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides are a heterogeneous group of rare autoimmune conditions that cause inflammation of blood vessels with various manifestations. The 3 main ANCA–associated vasculitides are granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with ...

anca 是 aav 的血清标志物，免疫荧光下可分为胞浆型（canca）和核周型（panca）。髓过氧化物酶（mpo）和蛋白酶 3（pr3）是 anca 主要的靶抗原，用 elisa 法检测可将 anca 分为 mpo-anca 和 pr3-anca。

The C-ANCA pattern is largely caused by autoantibodies targeting serine protease proteinase-3 (PR3-ANCA), while the P-ANCA pattern is caused by antibodies binding to many antigens among which myeloperoxidase (MPO-ANCA) is the most frequent target in primary systemic vasculitis .

抗中性粒细胞胞质抗体（ANCA）相关性血管炎（AAV）主要以小血管壁的炎性反应和纤维素样坏死为病理表现，伴随血清ANCA阳性，累及全身多系统的自身免疫性疾病。 主要临床表现包括：显微镜下多血管炎（MPA），肉芽肿性多血管炎（GPA），嗜酸性肉芽肿性多血管炎（EGPA）等。 最常见累及器官包括呼吸道及肾脏，病情凶险，死亡率高。 本文旨在综述AAV发病机制及治疗方法的最新研究进展。 胡剑 , 高春林 , 张沛 , 夏正坤. 抗中性粒细胞胞质抗体相关性血管炎发病机 …

2019年1月10日 · Objective: To provide a comprehensive review of the central nervous system (CNS) involvement in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including the pathogenesis, clinical manifestations, ancillary investigations, differential diagnosis, and …

ANCA vasculitis is a type of autoimmune disease that causes vasculitis. ANCA stands for Anti-Neutrophilic Cytoplasmic Autoantibody. All of these terms will be explained here, including how the disease works and what we can do for it.

2013年1月1日 · Clinical, in vitro, and experimental animal observations indicate that antineutrophil cytoplasmic autoantibodies (ANCA) are pathogenic. The genesis of the ANCA autoimmune response is a multifactorial process that includes genetic predisposition, environmental adjuvant factors, an initiating antigen, and failure of T cell regulation.

An antineutrophil cytoplasmic antibodies (ANCA) test is a blood test that detects ANCAs in your blood. ANCAs are proteins made by the immune system that mistakenly target neutrophils, infection-fighting white blood cells. ANCA testing helps healthcare providers diagnose and monitor certain types of vasculitis and inflammatory bowel disease.

2020年8月27日 · The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and...