The use of ERK inhibitors can downregulate Ang2 and CXCR4 to control the liver metastasis in colon cancer . It can be seen that Ang2 plays a key role in liver metastasis of colorectal cancer. Targeted inhibition of Ang2 or RAS-ERK1/2 axis can prevent and treat patients with liver metastasis of colorectal cancer .

Ang1 and Ang2 were shown to stimulate Tie2-independent cell adhesion of ECs and fibroblasts to Ang1- or Ang2-coated surfaces through α 5 β 1 and α v β 5 integrin–mediated activation of ERK and focal adhesion kinase (FAK) signaling . Skeletal myocytes lacking Tie2 adhere to Ang1- and Ang2-coated surfaces in a similar manner as to laminin ...

Ang1 binding to Tie2 in EC–ECM contacts represents the cis association mode, which preferentially activates the Erk and DokR pathways (10, 18). In contacting ECs, both angiopoietin ligands induce Tie2 translocation to cell–cell junctions, but Ang2 induces only weak Tie2 activation (10, 18).

ang2表达与肿瘤进展、生长联系密切，在药物靶点、预后标志物和癌症抑制物研究中具有巨大潜力。 TIE2靶向药物研究处于开发早期阶段。 因此ANG2-TIE2轴是目前肿瘤免疫治疗药物研究的热点之一。

These data indicate that ERK activation is induced by ANG2 in podocytes by mechanisms involving ANG2-dependent release of HB-EGF which, in turn, may act in an autocrine and paracrine fashion to stimulate ERK activity.

2022年2月16日 · 当Ang-1与Tie-2结合后，激活下游AKT和ERK通路，这两条通路参与减少血管生成和血管通透性，有利于血管稳定。 而Ang-2与Tie-2竞争性结合，抑制Tie-2磷酸化，从而促进血管生成。

2020年10月6日 · Ang2抑制剂(Ang2-blocking antibody, ABA)能特异性阻断Ang2, 使肿瘤异常血管减少, 其联合化疗药物可加强肿瘤内部的血液灌注和药物递送, 改善肿瘤的缺氧和酸中毒状态, 抑制肿瘤生长和转移, 破坏肿瘤微环境 。

2013年9月1日 · Angiopoietin2 (Ang2) promotes HepG2 cell from doxorubicin induced apoptosis via upregulation of Survivin and Ref-1. Ang2 activates ERK-MSK cascade to induce histone H3 phosphorylation and anti-apoptotic gene expression. Activation of MSK1 by Ang2 phosphorylates the CREB and the phosho-CREB is recruited to Ref-1 promoter.

2014年1月24日 · Here, we show that the expression of Angiopoietin-2 (Ang2) in LSECs is dynamically regulated after partial hepatectomy. During the early inductive phase of liver regeneration, Ang2 down-regulation leads to reduced LSEC transforming growth factor–β1 production, enabling hepatocyte proliferation by releasing an angiocrine proliferative brake.

2023年11月27日 · ang2作为血管生成的自分泌早期启动剂，首先使静止的血管失稳，从而允许vegf驱动血管生成血管芽的增殖和趋化性迁移。ang2还激活表达tie2的单核细胞/巨噬细胞（tem），它们具有自身的促血管生成、促肿瘤形成、促转移和免疫抑制功能。