Selective estrogen receptor modulators (SERMs) are a class of compounds that competitively bind to both nuclear and plasma membrane estrogen receptors to inhibit estrogen-induced breast tumor proliferation. (1-7) SERMs have also been shown to promote growth in bone, heart, and brain cells and are currently prescribed to prevent osteoporosis in p...

2023年7月24日 · SERM（选择性雌激素受体调节剂（selective estrogen receptor modulator））是一类激素或非激素类物质，主要通过抑制E2对肿瘤细胞DNA表达和生长代谢的特异性刺激而发挥作用。 抗雌激素类药物与ER结合以及对E2的抑制可以使肿瘤细胞生长停留在G1早期，从而抑制细胞增殖和减少S期细胞的比例。 除了直接的抑制作用外，其他一系列作用机制包括以下方面。 ①抑制体内最主要的循环雌激素形式硫酸雌酮的去硫酸化，这可以 显著降低游离的E2。 ②提高性激 …

2016年10月4日 · Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target ...

Selective estrogen receptor modulators (SERMs) are a class of compounds that competitively bind to both nuclear and plasma membrane estrogen receptors to inhibit estrogen-induced breast tumor proliferation. (1-7) SERMs have also been shown to promote growth in bone, heart, and brain cells and are currently prescribed to prevent osteoporosis in p...

Selective estrogen receptor modulators (SERMs), which exhibit estrogen receptor agonist or antagonist activity based on the target tissue, have evolved through multiple generations for the prevention and/or treatment of postmenopausal osteoporosis. An ideal SERM would protect bone without stimulating the breast or endometrium.

2022年12月15日 · Selective Estrogen Receptor Modulators (SERMs), which specifically control the ERs and limit the progression of breast malignancy, have drawn the interest of researchers in the treatment of breast cancer by regulation of the estrogen receptors (ER), particularly ERα.

Selective estrogen receptor modulator (SERM) interacts with estrogen receptors and acts as both an agonist or an antagonist, depending on the target tissue. SERM is widely used as a safer hormone replacement therapeutic medicine for postmenopausal ...

2024年5月26日 · The short external rotator muscles (SERMs) of the hip are composed of six postural muscles that constitute a single functional unit that is aligned to coapt the articular surfaces of the hip joint, providing dynamic stability. This study aims to provide a morphometric evaluation of this unit that could benefice clinical practice.

2016年11月2日 · serm类药物降低患者体内雌激素水平，同时又具有部分雌激素作用，故可影响血脂代谢，最终引起血脂异常，临床中serm类药物更常见的血脂异常表现为甘油三酯水平升高。

Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), [1] [2] are a class of drugs that act on estrogen receptors (ERs). [3] Compared to pure ER agonists – antagonists (e.g., full agonists and silent antagonists ), SERMs are more tissue-specific, allowing them to selectively inhibit or ...