Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin - actin based membrane cytoskeleton. [2] . Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins.

锚蛋白 (ankyrin)属于联结蛋白家族,广泛存在于各种 组织细胞 中。 锚蛋白连接 整合膜蛋白 到 细胞骨架 蛋白网络,在多种细胞功能活动中起关键作用,参与机体生长、发育、细胞内蛋白转运、细胞极性的建立和维持、细胞黏附、信号传导以及mRNA转录等。 对锚蛋白功能的研究将有助于阐明与其异常相关疾病的发病机制,为基因诊断和治疗提供理论基础。 锚蛋白 (ankyrin)属于联结蛋白家族,广泛存在于各种组织细胞中。

Ankyrin repeats typically fold together to form a single, linear solenoid structure called ankyrin repeat domains. These domains are one of the most common protein–protein interaction platforms in nature. They occur in a large number of functionally diverse proteins, mainly from …

2022年7月6日 · Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder...

Ankyrins are broadly expressed adaptors that organize diverse membrane proteins into specialized domains and link them to the sub-membranous cytoskeleton. In neurons, ankyrins are known to have essential roles in organizing the axon initial segment and nodes of Ranvier.

视觉研究步子迈得最快，19世纪就由德国生理学家Franz Christian Boll发现了光受体蛋白视紫红质rhodopsin在视网膜视杆细胞上的表达，之后美国科学家George Wald通过生物化学手段揭示rhodopsin感光的生化反应，并因此获得了1967年的诺贝尔生理学奖。 之后是嗅觉研究，美国科学家 Richard Axel （【致敬】换方向后获诺奖的大师Richard Axel）和他的博后 Linda B. Buck 于1991年一起在 Cell 杂志上发表工作 A novel multigene family may encode odorant receptors: …

2020年11月24日 · Ankyrins (Ank) are ubiquitously expressed proteins that play a critical role in the integrity of cytoskeleton and cellular signalling. Their presence in metazoans and evolutionary conserved protein primary sequence indicates their functional significance.

Recent data on characteristics of the structure, functions, and main properties of ankyrins (proteins that are linkers between the spectrin-based cytoskeleton and integral membrane proteins) are summarized. The interactions of ankyrins with band-3 protein, P-type ATPases, ion channels, receptors, and protein kinase C are considered.

锚定蛋白 (ankyrin)又称带2.1蛋白。 锚定蛋白是一种比较大的细胞内连接蛋白， 每个红细胞约含10万个锚定蛋白， 相对分子质量 为215,000。 锚定蛋白基因定位于第8号染色体P11.2区段，大小约为160kb，其中5’端215bp是红细胞ankyrin蛋白特有的具有启动子活性的基因片段。 发现多细胞动物中有大量的ankyrin的异构体以行使不同的功能。 脊椎动物共有三种ankyrin的基因 (ank1-3)编码了三个ankyrin蛋白家族分别为ankyrinR,B和G，通过选择性剪切和选择性的外显予表达会产 …

2006年12月26日 · Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of …