2024年2月21日 · Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca 2+ levels. Through this they act as Ca 2+ -regulated...

Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms (animals, plants and fungi). In humans, the annexins are found inside the cell. However some annexins (Annexin A1, Annexin A2, and Annexin A5) can be secreted from the cytoplasm to outside cellular environments, such as blood.

The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family – annexin VI – having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals.

2004年5月4日 · More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla, but annexins are absent from yeasts and prokaryotes. The unique annexin core domain is made up of four similar repeats approximately 70 amino acids long, each of which usually contains a characteristic 'type 2' motif for binding calcium ions.

Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved multigene family with members of the family being expressed throughout animal and plant kingdoms. Structurally, annexins are characterized by a highly alpha-helical and tightly packed protein core domain considered …

2025年2月15日 · Annexins are a family of calcium-dependent phospholipid-binding proteins involved in crucial cellular processes such as cell division, calcium signaling, vesicle trafficking, membrane repair, and apoptosis. In addition to these properties, Annexins have also been shown to bind RNA, although this function is not universally recognized.

Recent structural analyses of several annexin genes have provided insights into the relationship between exon organization and functional domains. We discuss the implications of these findings and speculate on the evolutionary origins of the annexin supergene family.

2005年6月1日 · Annexins are a multigene family of Ca 2+ -regulated proteins that are characterized by a unique Ca 2+ - and membrane-binding module — the annexin core domain. This core domain enables Ca 2+...

2 天之前 · The carboxyl core domain is typically divided into four homologous domains of approximately 70 residues. In all members, the core of these proteins is composed of four of these domain repeats, except for annexin A6 which contains eight of these fragments (Fig. 1 A). These domains adopt a four α-helix bundle structural motif that is capped by a ...

Annexins (ANX) are a large family of calcium-dependent membrane-binding proteins. They are widely distributed among eukaryotes but largely absent in prokaryotes and yeasts. The first protein of this family, discovered in 1977, was called synexin.