Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2]

在分子生物学中，AP-1转录因子（激活蛋白1，英語： activator protein 1 ，AP-1）是一种异二聚体蛋白转录因子，由c-Fos、c-Jun、JDP以及ATF家族的不同蛋白组成，调节基因表达以响应多种外界信号，如细胞因子、生长因子、环境压力以及细菌和病毒 感染 [1] ，与细胞分化 ...

Fos 家族和 Jun 家族相互作用形成同源或异源二聚体，称为 AP-1（activator protein-1，转录激活蛋白-1），是转录因子的典型代表。 Fos 蛋白家族包括 c-Fos、Fos-B、Fra-1、Fra-2 ；

AP-1 is another redox-sensitive transcription factor, which regulates cellular proliferation and differentiation during the neoplastic transformation [52]. AP-1 is composed of dimers between the Fos (c-Fos, FosB, Fra-1, and Fra-2) and the Jun (c-Jun, JunB, and JunD) family members.

The dimeric transcription factor complex Activator Protein-1 (AP-1) is a group of proteins involved in a wide array of cell processes and a critical regulator of nuclear gene expression during T-cell activation. It is also one of the downstream targets of the MAPK signaling cascade.

Here, we focus on the JUN and FOS proteins and aim to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site. As the complexity of our knowledge of AP-1 …

2020年4月7日 · 激活蛋白-1(activator protein-1，AP-1) 是调节细胞生长和分化最为关键的转录因子之一，其作为启动基因转录的分子开关，参与细胞增殖、分化和凋亡等重要的生物学过程。

激活蛋白-1(activator protein-1,AP-1)是细胞内一类转录激活因子,主要由原癌基因编码的蛋白质Jun和Fos组成,以同源或异源二聚体复合物形式结合DNA靶序列,调控靶基因表达.AP-1通过调节靶基因表达来应对多种刺激(包括细胞因子,生长因子,压力及细菌和病毒感染等)对细胞的 ...

ap-1上调含有tpa dna 应答元件 (tre; 5'-tgag/ctca-3') 的基因的转录。 AP-1异二聚体通过 亮氨酸拉链 形成，并通过特定的 保守序列 与基因结合来启动基因的表达。