An antigen-presenting cell (APC) or accessory cell is a cell that displays an antigen bound by major histocompatibility complex (MHC) proteins on its surface; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T cells.

Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin …

An antigen-presenting cell (APC) is an immune cell that detects, engulfs, and informs the adaptive immune response about an infection. When a pathogen is detected, these APCs will phagocytose the pathogen and digest it to form many different fragments of the antigen.

2023年8月31日 · Describe the overall function of antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B-lymphocytes in terms of the following: how they "process" exogenous antigens how they "process" endogenous antigens the types of MHC molecule to which they attach peptides the role of proteasomes in the binding of peptides from endogenous...

Antigen-presenting cell (APC) refers to the ability of certain cells, including macrophages, dendritic cells, and B lymphocytes to take up, process, and present antigenic peptides to naive CD4 + T cells in the context of major histocompatibility complex class II (MHC class II) and co-stimulatory molecules. The once prevalent view that the ...

2011年6月2日 · The APC/C (anaphase-promoting complex, also known as the cyclosome) is a multisubunit ubiquitin ligase that regulates the cell cycle by targeting different substrates for degradation at different...

The field of antigen presenting cell (APC) biology is commonly considered mature by immunologists, with most key mechanisms being explored and established in detail. Thorough understanding of APC biology has helped providing the fundaments, to name recent examples, for deciphering antiviral immune responses in the SARS-CoV2 pandemic, or to ...

2025年1月22日 · Antigen-presenting cells (APCs) primarily ingest pathogens by phagocytosis, destroy them in the phagolysosomes, process the protein antigens, and select the most antigenic/immunodominant epitopes with MHC II for presentation to T cells.

2003年3月18日 · APC is short for adenomatous polyposis coli. The APC gene is mutated in familial adenomatous polyposis, a hereditary form of colon cancer. Carriers of APC mutations develop thousands of colon tumours, some of which inevitably progress to malignancy.

2024年10月17日 · Revision notes on The Role of Antigen-Presenting Cells for the AQA A Level Biology syllabus, written by the Biology experts at Save My Exams.